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Description
IL-12/IL-23 p40 Homodimer Protein, MouseProduct Specification Species Mouse Synonyms Interleukin 12 subunit beta,IL 12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40),IL 12 subunit p40 Accession P43432 Amino Acid Sequence Met23 Ser335 Expression System HEK293 Molecular Weight 43 45 kDa (Reducing) Purity >95% by SDS PAGE. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at
Product Specification
| Species | Mouse |
| Synonyms | Interleukin-12 subunit beta,IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit (CLMF p40),IL-12 subunit p40 |
| Accession | P43432 |
| Amino Acid Sequence | Met23-Ser335 |
| Expression System | HEK293 |
| Molecular Weight | 43-45 kDa (Reducing) |
| Purity | >95% by SDS-PAGE. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Annu Rev Immunol. 1998:16:495-521. |
Background
Interleukin-12 (IL-12) is a heterodimeric cytokine composed of two disulfide-linked subunits, p35 and p40. It plays a crucial role in regulating immune responses, particularly in promoting the differentiation of T helper 1 (Th1) cells and enhancing the cytotoxic activity of natural killer (NK) cells. The p40 subunit is shared between IL-12 and IL-23, another important cytokine involved in immune regulation. In mice, IL-12 p40 is produced by various immune cells, including macrophages, dendritic cells, and B cells. The p40 subunit can also exist as a homodimer or monomer, which can act as an antagonist to IL-12.
The p40 subunit is a target for therapeutic interventions in autoimmune and inflammatory diseases. Monoclonal antibodies against IL-12 p40 have been developed to inhibit its activity and reduce inflammation. Also, IL-12 has potent antitumor activity by stimulating the immune system to attack cancer cells. Recombinant IL-12 or IL-12 vectors are being explored as potential cancer treatments.
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