SKU: 95986887472

Histone H3 (tri methyl K4) Recombinant Rabbit mAb (S-4099)

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Description

Histone H3 (tri methyl K4) Recombinant Rabbit mAb (S-4099)Product Specification Host Rabbit Antigen Histone H3 (tri methyl K4) Synonyms H3K4me3 Location Nucleus Accession P68431 Clone Number S 4099 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC, ChIP Reactivity Hu, Ms, Rt Positive Sample HeLa, NIH 3T3, C6 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12

Product Specification


Host Rabbit
Antigen Histone H3 (tri methyl K4)
Synonyms H3K4me3
Location Nucleus
Accession P68431
Clone Number S-4099
Antibody Type Recombinant mAb
Isotype IgG
Application WB, ICC, ChIP
Reactivity Hu, Ms, Rt
Positive Sample HeLa, NIH/3T3, C6
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20°C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt
ICC 1:500 Hu, Ms
ChIP 1:20-1:50 Hu

Background

Histone H3 lysine 4 trimethylation (commonly denoted as H3K4me3) is a crucial epigenetic modification on the tail of core histone H3 that plays a central role in regulating gene transcription. It is primarily catalyzed by histone methyltransferases from the COMPASS/COMPASS-like family (such as MLL1-4 and SET1A/B) and is specifically recognized by "reader" proteins containing PHD domains (e.g., Taf3 and ING family proteins). The genomic distribution of H3K4me3 is highly characteristic: it is strongly enriched at the promoter regions of actively transcribed genes, particularly near transcription start sites, marking a "primed for activation" state. This modification facilitates the formation of open chromatin structures and the assembly of the transcription initiation complex by recruiting chromatin remodelers, general transcription factors, and histone acetyltransferases, thereby positively regulating gene expression. H3K4me3 is essential for maintaining pluripotency in embryonic stem cells, cell fate determination, and processes such as learning and memory. Notably, its dysregulation—whether excessive or deficient—is closely associated with various developmental disorders and cancers (such as leukemia and breast cancer). Consequently, H3K4me3 is not only a vital biomarker in fundamental research but also a potential target for disease diagnosis and therapy.

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SKU: 95986887472

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Alyssa Kilian
Lowell, US
★★★★★ 5
Such a pampering treat!
Color: Pink (PDRN)
Ok I love these!!! I’ve started using them almost every morning! They just feel like a little pamper before I start my day. They definitely tighten up my under eye and decrease puffiness. I try to leave them on for 25 min or so. Maybe not quite as good as the Peter Roth but I feel like I can use them frequently due to the reasonable price point and still see some results. I save the Peter Roth for a couple times a month. Definitely repurchasing these.
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Reviewed in the United States on May 7, 2026
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Amber Arnold
West Palm Beach, US
★★★★★ 4
Hydrates well
Color: Pink (PDRN)
So far the product has been nice. My understanding is that eye area looks hydrated. It does not diminish the under eye bags. Have been using for a few weeks. Maybe I’ll give it more time to see better results.
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Reviewed in the United States on April 1, 2026
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Vero
Grantham, US
★★★★★ 5
Super hydrating!!
Color: Pink (PDRN)
I love theses eye patches so much! Not only are they very hydrating for the under eye but the price point is *chefs kiss*! They stay in place and do not slide all over your face. Super easy to use. 10/10
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Reviewed in the United States on May 31, 2026
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Whit
Lake Worth, US
★★★★★ 5
Eye patches that work
Color: Pink (PDRN)
Love them! Cooling to the eyes, easy to apply with no slipping. These eyes patches work and they’re great for the price. The only patches I’ll buy going forward. I just apply my eye cream first and then follow with the patches and you can definitely see the results once removing.
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Reviewed in the United States on May 28, 2026
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Teri
Fort Morgan, US
★★★★★ 5
Stuff works
Color: Pink (PDRN)
Absolutely love this stuff. It tightened up your skin. it's lightweight. you can leave it on all night long, if you wish. and you can really see the difference in the morning. Also gives you that glossy pretty skin look.
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Reviewed in the United States on May 28, 2026

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