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Description
NMDA Receptor 2A (GluN2A) Recombinant Rabbit mAb (S-2126-168)Product Specification Host Rabbit Antigen NMDA Receptor 2A (GluN2A) Synonyms Glutamate receptor ionotropic, NMDA 2A; GluN2A; Glutamate [NMDA] receptor subunit epsilon 1; N methyl D aspartate receptor subtype 2A (NMDAR2A; NR2A; hNR2A); NMDAR2A; GRIN2A Immunogen Synthetic Peptide Location Cell membrane Accession Q12879 Clone Number S 2126 168 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms Positive Sample mouse brain
Product Specification
| Host | Rabbit |
| Antigen | NMDA Receptor 2A (GluN2A) |
| Synonyms | Glutamate receptor ionotropic, NMDA 2A; GluN2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A (NMDAR2A; NR2A; hNR2A); NMDAR2A; GRIN2A |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | Q12879 |
| Clone Number | S-2126-168 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Positive Sample | mouse brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
Background
NMDA Receptor 2A (GluN2A) is a critical subunit of the N-methyl-D-aspartate (NMDA) receptor, a subtype of ionotropic glutamate receptor that plays a pivotal role in synaptic plasticity, learning, and memory; GluN2A-containing receptors are highly expressed in the adult forebrain, exhibit faster kinetics and higher open probability than GluN2B-containing receptors, and their proper trafficking, phosphorylation, and interaction with scaffolding proteins such as PSD-95 are essential for regulating synaptic strength, with dysregulation or mutations in GRIN2A (the gene encoding GluN2A) linked to neurodevelopmental disorders including intellectual disability, epilepsy, and schizophrenia.
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