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Description
Invivo anti-Mouse I-A/I-E Recombinant mAbProduct Specification Host Rat Antigen I A I E Synonyms H 2 class II histocompatibility antigen, I A beta chain; H2 Eb1 Location Membrane Accession P18468 Q3U060 Clone Number S R511 Antibody Type Rat mAb Isotype Rat IgG2b,k Application FCM, Functional assays, in vivo MHC II blockade Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 5 mg ml Purity >95% (Determined by SDS PAGE) Endotoxin <1EU mg Conjugation
Product Specification
| Host | Rat |
| Antigen | I-A/I-E |
| Synonyms | H-2 class II histocompatibility antigen, I-A beta chain; H2-Eb1 |
| Location | Membrane |
| Accession | P18468、 Q3U060 |
| Clone Number | S-R511 |
| Antibody Type | Rat mAb |
| Isotype | Rat IgG2b,k |
| Application | FCM, Functional assays, in vivo MHC II blockade |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 5 mg/ml |
| Purity | >95% (Determined by SDS-PAGE) |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| FCM | 1:500 | Ms |
Background
I-A/I-E proteins are part of the Major Histocompatibility Complex (MHC) class II molecules, which are heterodimeric transmembrane glycoproteins expressed on antigen-presenting cells such as dendritic cells, macrophages, and B cells. These proteins are encoded by four genes located in the mouse MHC and are composed of α and β subunits. The I-A and I-E molecules are highly polymorphic and can form hybrid molecules in heterozygous individuals, contributing to the diversity of antigen presentation. They play a crucial role in presenting peptide antigens to CD4+ helper T cells, initiating adaptive immune responses. Additionally, MHC class II molecules can trigger intracellular signaling pathways in antigen-presenting cells, influencing their proliferation, maturation, and apoptosis.
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Exchange/Return Notes
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