SKU: 97383272140

MARCKS Recombinant Rabbit mAb (S-3190-72)

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Description

MARCKS Recombinant Rabbit mAb (S-3190-72)Product Specification Host Rabbit Antigen MARCKS Synonyms Myristoylated alanine rich C kinase substrate; Protein kinase C substrate; 80 kDa protein; light chain (80K L protein; PKCSL); MACS; PRKCSL Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Cell membrane Accession P29966 Clone Number S 3190 72 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample A431, HEK 293 Purification Protein A

Product Specification


Host Rabbit
Antigen MARCKS
Synonyms Myristoylated alanine-rich C-kinase substrate; Protein kinase C substrate; 80 kDa protein; light chain (80K-L protein; PKCSL); MACS; PRKCSL
Immunogen Synthetic Peptide
Location Cytoplasm, Cytoskeleton, Cell membrane
Accession P29966
Clone Number S-3190-72
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, ICC
Reactivity Hu
Positive Sample A431, HEK-293
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:500 Hu
ICC 1:500 Hu

Background

MARCKS (Myristoylated Alanine-Rich C Kinase Substrate) is an evolutionarily conserved, intrinsically disordered peripheral membrane protein that serves as a key phosphorylation substrate for conventional and novel protein kinase C isoforms; by reversibly sequestering phosphatidylinositol-4,5-bisphosphate (PIP2) and cross-linking actin filaments, it integrates PKC, Ca2+/calmodulin, and small GTPase signaling to orchestrate dynamic membrane-cytoskeleton remodeling underlying cell adhesion, migration, endo/exocytosis, neurotransmitter release, and stem-cell differentiation, while its dysregulation contributes to cancer metastasis, inflammatory diseases, and neuronal disorders.

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SKU: 97383272140

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