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Description
NGAL Recombinant Rabbit mAb (SDT-473-240)Product Specification Host Rabbit Antigen NGAL Synonyms Lipocalin 2, Neutrophil gelatinase associated lipocalin Immunogen Recombinant Protein Accession P80188 Clone Number SDT 473 240 Antibody Type Recombinant mAb Isotype IgG Application CLIA, Sandwich ELISA Reactivity Hu Cross Reactivity No cross reactivity against CRP and KIM 1 Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical Appearance Liquid
Product Specification
| Host | Rabbit |
| Antigen | NGAL |
| Synonyms | Lipocalin-2, Neutrophil gelatinase-associated lipocalin |
| Immunogen | Recombinant Protein |
| Accession | P80188 |
| Clone Number | SDT-473-240 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | CLIA, Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | No cross-reactivity against CRP and KIM-1 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Purity | >95% by HPLC |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a 25 kDa protein that plays a crucial role in the early diagnosis and monitoring of various diseases, particularly acute kidney injury (AKI) and diabetic nephropathy (DN). NGAL is highly sensitive and specific for detecting AKI, often rising within 2 hours post-injury, well before serum creatinine levels change. This makes it a valuable tool for early intervention, especially in high-risk patients such as those undergoing cardiac surgery or exposed to nephrotoxic agents. In diabetic patients, NGAL serves as an early indicator of renal tubular injury, often preceding the appearance of microalbuminuria. Studies have shown that elevated urinary NGAL levels correlate with the progression of DN, making it a promising biomarker for early detection and management. NGAL is a versatile biomarker with significant clinical utility in early diagnosis, prognosis, and monitoring of kidney-related and other systemic diseases. Its ability to provide early and accurate insights makes it a valuable tool in modern medicine.
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