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Description
Biotin Mouse Anti-Human NKp44 (CD336) Antibody (S-3122)Product Specification Host Mouse Antigen NKp44 (CD336) Synonyms Natural cytotoxicity triggering receptor 2; Lymphocyte antigen 95 homolog; NK cell activating receptor; Natural killer cell p44 related protein (NK p44; NKp44); LY95; NCR2 Location Cell membrane Accession O95944 Clone Number S 3122 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance
Product Specification
| Host | Mouse |
| Antigen | NKp44 (CD336) |
| Synonyms | Natural cytotoxicity triggering receptor 2; Lymphocyte antigen 95 homolog; NK cell-activating receptor; Natural killer cell p44-related protein (NK-p44; NKp44); LY95; NCR2 |
| Location | Cell membrane |
| Accession | O95944 |
| Clone Number | S-3122 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
NKp44 (CD336, NCR2) is a 44-kDa type I transmembrane glycoprotein of the immunoglobulin superfamily expressed exclusively on activated human NK cells (induced by IL-2 or IL-15) and on minor subsets of γδ T cells, ILC1/3 and plasmacytoid dendritic cells; it functions as an activating natural cytotoxicity receptor that, upon engagement with still-undefined cellular ligands, associates via a positively charged transmembrane residue with the ITAM-bearing adaptor DAP12 (KARAP) to trigger NK-cell cytotoxicity and secretion of IFN-γ and TNF-α against tumor or virus-infected targets, while a cytoplasmic ITIM sequence can also mediate inhibitory signals, giving the receptor dual functionality and making its selective expression a key activation marker whose reduction, as seen in HIV infection, correlates with impaired NK-cell activity.
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