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Description
NLRP3 Recombinant Rabbit mAb (S-2613-140)Product Specification Host Rabbit Antigen NLRP3 Synonyms NACHT, LRR and PYD domains containing protein 3; Cold autoinflammatory syndrome 1 protein homolog; Cryopyrin; Mast cell maturation associated inducible protein 1; PYRIN containing APAF1 like protein 1; Cias1; Mmig1; Nalp3; Pypaf1; Nlrp3 Immunogen Recombinant Protein Location Cytoplasm, Cytoskeleton, Nucleus, Secreted, Mitochondrion, Endoplasmic reticulum Accession Q8R4B8 Clone Number S 2613 140
Product Specification
| Host | Rabbit |
| Antigen | NLRP3 |
| Synonyms | NACHT, LRR and PYD domains-containing protein 3; Cold autoinflammatory syndrome 1 protein homolog; Cryopyrin; Mast cell maturation-associated-inducible protein 1; PYRIN-containing APAF1-like protein 1; Cias1; Mmig1; Nalp3; Pypaf1; Nlrp3 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Cytoskeleton, Nucleus, Secreted, Mitochondrion, Endoplasmic reticulum |
| Accession | Q8R4B8 |
| Clone Number | S-2613-140 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms |
| Positive Sample | J774A.1, RAW264.7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
Background
NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) is a ~118 kDa cytosolic pattern-recognition receptor that assembles into the macromolecular “NLRP3 inflammasome” when confronted by a structurally diverse set of microbial toxins, RNA viruses, extracellular ATP, crystalline substances or metabolic danger signals; upon activation NLRP3 nucleates the adaptor ASC and pro-caspase-1 filaments, driving caspase-1–mediated proteolytic maturation of interleukin-1β/18 and gasdermin D, which triggers pyroptotic cell death and amplifies systemic inflammation, thereby placing NLRP3 at the hub of innate immunity, autoinflammatory syndromes and chronic metabolic disorders such as gout, atherosclerosis, Alzheimer’s disease and type-2 diabetes.
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Exchange/Return Notes
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