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Description
Rat Anti-Mouse CD163 Antibody (S-R608)Product Specification Host Rat Antigen Mouse CD163 Location Cell membrane Accession B7ZMW6 Clone Number S R608 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse bone marrow Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date of receipt reconstitution, 2 to 8 C as supplied. Dilution application
Product Specification
| Host | Rat |
| Antigen | Mouse CD163 |
| Location | Cell membrane |
| Accession | B7ZMW6 |
| Clone Number | S-R608 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse bone marrow |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 1:200 | Ms |
Background
CD163 is a type I membrane protein primarily expressed on the surface of monocytes and macrophages and belongs to the scavenger receptor cysteine-rich (SRCR) superfamily. It plays a crucial role in regulating immune responses and clearing heme proteins. CD163 binds to haptoglobin-hemoglobin complexes, facilitating iron recycling and protecting tissues from oxidative damage. As a marker of M2-type macrophages, CD163 is associated with anti-inflammatory functions by inhibiting the production of pro-inflammatory cytokines. In pathological conditions, the expression levels of CD163 are linked to various diseases, including inflammatory disorders, cancer, and viral infections. Soluble CD163 (sCD163) is often used as a biomarker for disease monitoring and assessment.
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