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Description
E-Selectin/CD62E His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms LECAM2, ELAM1, Endothelial leukocyte adhesion molecule 1, ELAM 1, SELE, Selectin E, CD62 Antigen Like Family Member E, Endothelial Adhesion Molecule 1, Leukocyte Endothelial Cell Adhesion Molecule 2, CD62E Antigen, ESEL, ELAM, Leukocyte Endothelial Cell Adhesion Molecule 2 Accession XP_005539998. 2 Concentration 95% by SDS PAGE & SEC HPLC Amino Acid Sequence Trp22 Pro556 with His Tag at the C Terminus
Product Specification
| Species | Cynomolgus |
| Synonyms | LECAM2, ELAM1, Endothelial leukocyte adhesion molecule 1, ELAM-1, SELE, Selectin E, CD62 Antigen-Like Family Member E, Endothelial Adhesion Molecule 1, Leukocyte-Endothelial Cell Adhesion Molecule 2, CD62E Antigen, ESEL, ELAM, Leukocyte Endothelial Cell Adhesion Molecule 2 |
| Accession | XP_005539998.2 |
| Concentration | ＞95% by SDS-PAGE & SEC-HPLC |
| Amino Acid Sequence | Trp22-Pro556 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 90-110kDa (Reducing) |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 5% trehalose, PH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Liu ZJ, Tian R, An W, Zhuge Y, Li Y, Shao H, et al.. Identification ofE-selectin as a novel target for the regulation of post-natalneovascularization: implications for diabetic wound healing. Ann Surg. (2010)252:625–34. |
Background
E-Selectin, officially known as Endothelial Leukocyte Adhesion Molecule-1 (ELAM-1) or CD62E, is a member of the Selectin family of cell surface glycoproteins with a molecular weight ranging from 107 to 115 kDa. This cell adhesion molecule plays a pivotal role in inflammation and neovascularization, particularly in wound healing and ischemic areas.
Upon tissue injury, the release of cytokines and chemokines, such as stromal cell-derived factor 1α (SDF-1α), triggers the local expression of membrane-bound E-Selectin on endothelial cells. Concurrently, it induces the expression of systemic reciprocal E-Selectin ligands on endothelial progenitor cells (EPCs) within the bone marrow, mediated by the C-X-C motif chemokine receptor 4 (CXCR4).
E-Selectin is transiently expressed on vascular endothelial cells in response to cytokines like IL-1 beta and TNF-alpha, peaking at 4 hours post-activation and decaying by 24 hours. This cell surface glycoprotein is integral to immune cell adhesion, specifically by interacting with SELPLG/PSGL1 on blood neutrophils, which facilitates their adhesion to cytokine-activated endothelium. E-Selectin may also contribute to capillary morphogenesis.
During inflammation, E-Selectin mediates the attachment of flowing leukocytes to the blood vessel wall by binding to E-Selectin ligands present on leukocytes. These initial interactions are dynamic, allowing leukocytes to roll along the vascular endothelium in the direction of blood flow. Subsequently, stronger interactions involving ICAM-1 and VCAM-1 lead to the extravasation of white blood cells through the blood vessel wall and into the extracellular matrix of surrounding tissues.
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