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Description
NNT-1/BCSF-3 Protein, HumanProduct Specification Species Human Synonyms GNovel Neurtrophin 1 B Cell Stimulating Factor 3 Accession Q9UBD9 Amino Acid Sequence Leu28 Phe225 Expression System E. coli Molecular Weight Approximately 22. 3 kDa, a single non glycosylated polypeptide chain containing 198 amino acids. Purity 96% by SDS PAGE or HPLC. Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer 30% Acetonitrile and 0. 1% TFA. Reconstitution
Product Specification
| Species | Human |
| Synonyms | GNovel Neurtrophin-1/B-Cell Stimulating Factor-3 |
| Accession | Q9UBD9 |
| Amino Acid Sequence | Leu28-Phe225 |
| Expression System | E.coli |
| Molecular Weight | Approximately 22.3 kDa, a single non-glycosylated polypeptide chain containing 198 amino acids. |
| Purity | ＞96% by SDS-PAGE or HPLC. |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | 30% Acetonitrile and 0.1% TFA. |
| Reconstitution | Before use this product, please read the direction below carefully. This vial must be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in a sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20℃. Further dilutions should be made in appropriate buffered solutions. |
| Stability & Storage | For long term storage, the product should be stored ≤ -20℃. |
Background
Novel Neurotrophin-1 (NNT-1) or B-Cell Stimulating Factor-3 (BSF-3) , is a new member of the IL-6 family of structurally related cytokines that includes IL-6, CNTF, LIF, CT-1, IL-11 and OSM. All family members share the receptor subunit gp130 that belong to the type I cytokine receptor superfamily. Ligand binding leads to gp130 homodimerization or heterodimerization (with LIF receptor or OSM receptor beta) , and induces cell signaling and functional activity. For several family members, including CNTF, IL-6, and IL-11, binding of the ligand to a specific receptor alpha subunit (CNTF R alpha, IL-6 R alpha, or IL-11 R alpha) is required prior to gp130 homo- or hetero-dimerization. Recombinant human NNT-1/BCSF-3 a 22.3kDa protein containing 198 amino-acid residues.
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