SKU: 99798902218

Mouse Anti-Rat CD45R Antibody (S-3303)

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Description

Mouse Anti-Rat CD45R Antibody (S-3303)Product Specification Host Mouse Antigen CD45 Synonyms Receptor type tyrosine protein phosphatase C; Leukocyte common antigen (L CA); T200; CD45; Ptprc Location Cell membrane, Synapse Accession P04157 Clone Number S 3303 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity Rt Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability & Storage 12 months from date

Product Specification


Host Mouse
Antigen CD45
Synonyms Receptor-type tyrosine-protein phosphatase C; Leukocyte common antigen (L-CA); T200; CD45; Ptprc
Location Cell membrane, Synapse
Accession P04157
Clone Number S-3303
Antibody Type Mouse mAb
Isotype IgG2b,k
Application FCM
Reactivity Rt
Purification Protein A
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Background

CD45R is a critical splice variant of the CD45 protein, belonging to the receptor-type protein tyrosine phosphatase (RPTP) family. It is primarily expressed on the surface of B cells, monocytes, and certain T cell subsets. As a transmembrane glycoprotein, its extracellular region contains domains (A, B, C) encoded by variable exons, forming diverse isoforms (e.g., CD45RA, CD45RB). These domain variations influence glycosylation patterns and ligand-binding properties. The core function of CD45R lies in its intracellular phosphatase domain, which specifically dephosphorylates the C-terminal inhibitory tyrosine residues of Src family kinases (such as Lck and Fyn). This action positively regulates the initiation and activation threshold of lymphocyte receptor signaling pathways, playing a vital role in B cell development, activation, and the fine-tuning of immune responses. Changes in its expression pattern often serve as markers for lymphocyte differentiation and activation status (e.g., CD45RA+ denotes naive T cells), holding significant value in immunology research and the clinical diagnosis of immune-related diseases.

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SKU: 99798902218

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Magpie
Los Angeles, US
★★★★★ 3
Get their newer version. These were too flat.
Really thin/flat pillows
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Reviewed in the United States on May 11, 2026
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Amazon Customer
Boise, US
★★★★★ 2
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I bought these pillows based on customer reviews. I got them and let them poof out after opening... But they are awful. They're soft but there's nothing to them. Very flat and not supportive. I'm literally buying different pillows tomorrow.
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Reviewed in the United States on April 25, 2026
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Chrissy27
Natrona Heights, US
★★★★★ 5
Excellent
Extremely comfortable pillows. I would highly recommend
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Reviewed in the United States on May 25, 2026
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I love the color and how the covers fit. Delivery service was on time. I have absolutely no complaints. I plan to order another set of sofa and loveseat covers.
Boise, US
★★★★★ 5
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I love the comfort and quality of the pillows.
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Reviewed in the United States on May 29, 2026
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Laura Healy
Dallas, US
★★★★★ 5
So comfy
These pillows are great! So comfy, no neck or back pain. I highly recommend them!
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Reviewed in the United States on May 1, 2026

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