SKU: 99814925567

TNFRSF17/BCMA Recombinant Rabbit mAb (S-4674)

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Description

TNFRSF17/BCMA Recombinant Rabbit mAb (S-4674)Product Specification Host Rabbit Antigen TNFRSF17 BCMA Synonyms Tumor necrosis factor receptor superfamily member 17; B cell maturation protein; CD269 Location Cell membrane Accession Q02223 Clone Number S 4674 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample U266B1 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.

Product Specification


Host Rabbit
Antigen TNFRSF17/BCMA
Synonyms Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269
Location Cell membrane
Accession Q02223
Clone Number S-4674
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, ICC
Reactivity Hu
Positive Sample U266B1
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:100 Hu
ICC 1:500 Hu

Background

B-cell maturation antigen (BCMA, gene name TNFRSF17) is a member of the tumor necrosis factor receptor superfamily (TNFRSF) that is specifically expressed on late-stage B-cell lineage cells, including plasmablasts and long-lived plasma cells, while being virtually absent in normal tissues or early B-cells. As a key receptor for both BAFF (B-cell activating factor) and APRIL (a proliferation-inducing ligand), BCMA recruits TRAF adapter proteins to activate downstream signaling pathways such as NF-κB, MAPK, and PI3K/Akt, playing a central role in sustaining plasma cell survival, differentiation, and antibody secretion. Due to its highly restricted expression profile and its aberrant overexpression on multiple myeloma (MM) cells, BCMA has emerged as a premier therapeutic target; consequently, various BCMA-directed therapies, including chimeric antigen receptor T-cell (CAR-T) therapy, bispecific antibodies, and antibody-drug conjugates (ADCs), have demonstrated remarkable clinical efficacy, fundamentally transforming the treatment landscape for this disease.

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SKU: 99814925567

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4.6 ★★★★★
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Verified Purchase
Lisse
Charlottesville, US
★★★★★ 5
A great book by a great journalist
Format: Hardcover
The China Matrix is another great book by the great journalist Lee Smith. The book is written in a very easy to read format. I have learned so many things that I didn't know before, and I simply can't put it down. Lee opened my eyes about the way Washington D.C. works, and I really miss his Epoch TV show, Over the Target. I wish more shows invited him on because he has a great insight when it comes to domestic and international affairs. To whoever wants to learn more about the way the Chinese Community Party works, I recommend to get this book and read it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on November 1, 2025
B
Verified Purchase
Brett Norton
Grantham, US
★★★★★ 3
Misses some important context, but a solid book
Format: Audiobook
I can't give it the 3.5 stars it deserves. Smith is an outstanding writer and has long view China as an adversary that we intentionally do not pay attention to given the elites make large amounts of money working with the CCP. In this book he demonstrates that happened from the get go, starting with Kissinger. Rarely, if ever, were American interests ever viewed as the lens with which to see China, only as a way to make money for power brokers and businesses alike. He points to Trumps long standing opposition to the way the international trade system evolved and the way it harmed middle class Americans. All of this is outstanding, but the book loses many points trying to cover for terrible protectionist economic policies. We certainly may have gone too far in hollowing out the industrial base, but 100% of Americans benefitted from lower price and more selections. It is not the purpose of the book, but a look at overall US business policy has been to harm Amercians, one need look no further than mass immigration, legal and illegal that drive down wages at the lower/middle end. Nor does the book bother with looking at general business mindless following each other for yet another new fad, from six sigma to who moved my cheese. Again, not what the book is about, but he tries to make the claim that all of this is China and elite policy driving toward this outcome when that data is not supported. Overall, it is a better than worse book that one should read if for no other reason than to see how far we have actually bent over for China for gains that are mostly illusory for business access. That China still uses the elites to gain access not just to markets but US citizen minds is the real problem. Smith does a good job pointing that out
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 25, 2025
G
Verified Purchase
Grayfox41
Port Orchard, US
★★★★★ 5
Yet, so many US consumers take a knee to Chinese imports.
Format: Kindle
My first response to Lee Smith's "The Chinese Matrix" is anger with the CCP. But, they did what treasonous US politicians and investors permitted in exchange for wealth and power. The current situation reminds me of the Chinese finger trap - a small tube of woven reeds just large enough to insert a finger into each end. When naturally trying to withdraw the fingers from opposite ends, the woven reeds constricted. Escape was contrary to natural instinct. Likewise, to extract our country from the Chinese Matrix will require unnatural sacrifice.
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Reviewed in the United States on March 11, 2026
G
Verified Purchase
@Grampa_Steve
Omaha, US
★★★★★ 5
Comprehensive and bold analysis of US foreign policy with China.
Format: Kindle
Lee Smith takes the reader through the many years of China appeasement from Kissenger and Nixon to the present where China continues to suck the power of the US toward its goal of global domination.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 9, 2025
S
Verified Purchase
Steve
Dallas, US
★★★★★ 5
Excellent and relevant hid
Format: Hardcover
Translation was superb. Author’s insights on the human condition still very relevant for today’s world.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 25, 2026

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