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Description
PSAP Recombinant Rabbit mAb (S-2399-11)Product Specification Host Rabbit Antigen PSAP Synonyms Prosaposin; Proactivator polypeptide; GLBA; SAP1 Immunogen Synthetic Peptide Location Lysosome Accession P07602 Clone Number S 2399 11 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample PANC 1, PC 3, HeLa Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0.
Product Specification
| Host | Rabbit |
| Antigen | PSAP |
| Synonyms | Prosaposin; Proactivator polypeptide; GLBA; SAP1 |
| Immunogen | Synthetic Peptide |
| Location | Lysosome |
| Accession | P07602 |
| Clone Number | S-2399-11 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | PANC-1, PC-3, HeLa |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:250 | Hu |
Background
Prosaposin (PSAP) is a highly conserved, 68- to 73-kDa glycoprotein encoded by the PSAP gene on chromosome 10q22.1 that serves dual intracellular and extracellular roles: inside the endolysosomal system it is proteolytically cleaved into four small lysosomal activator proteins (saposins A–D) that bind either specific hydrolases or their glycosphingolipid substrates to enable sphingolipid catabolism, while outside the cell PSAP acts as a secreted neurotrophic factor that supports neuronal survival, neurite outgrowth and ERK signaling, can be endocytosed via LRP1 or CI-M6PR, and has recently been implicated in cancer progression, metastasis and as an emerging therapeutic target in tumors.
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