SKU: 31134758391

SkinCeuticals® Phloretin CF Serum 30mL

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Description

SkinCeuticals® Phloretin CF Serum 30mLPhloretin CF features a patented synergistic combination of 2% phloretin, 10% pure vitamin C (L ascorbic acid), and 0. 5% ferulic acid to for enhanced protection against atmospheric skin ageing environmental damage and premature signs of ageing caused by free radicals from UVA UVB, infrared radiation (IRA), and ozone pollution (O3). In addition to antioxidant protective benefits, Phloretin CF improves the appearance of discoloration, fine lines, and

Phloretin CF features a patented synergistic combination of 2% phloretin, 10% pure vitamin C (L-ascorbic acid), and 0.5% ferulic acid to for enhanced protection against atmospheric skin ageing – environmental damage and premature signs of ageing caused by free radicals from UVA/UVB, infrared radiation (IRA), and ozone pollution (O3). In addition to antioxidant protective benefits, Phloretin CF improves the appearance of discoloration, fine lines, and uneven skin tone.

How To Use

In the morning after cleansing and toning, apply 4-5 drops to a dry face, neck, and chest before other skincare products.

Visible Results

In-vivo, Phloretin CF provides a high level of environmental protection against UV-induced oxidative damage when exposed to solar-simulated light.

97% sunburn cell reduction. Protects against UVA/UVB - skin protected with Phloretin CF shows significantly lower levels of p53. p53 is an essential protective protein in skin, it's levels increase when skin is damaged. (Pinnell, S. Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin - JCD - 2008). 


Protects against ozone pollution - 47% reduction in NFkB activation. NFkB pathway is a marker of skin sensitisation in response to ozone pollution exposure (Valacchi, G. Protective Effects of Topical Vitamin C Compound Mixtures Against Ozone-Induced Damage in Human Skin - Journal of Investigative Dermatology - 2017). 
After 24 weeks, 24% reduction in fine lines, 16% improvement in skin texture, 19% reduction of dullness and discolouration. 


Proven to be safe when used post CO2 -78˚C cryotherapy treatment. Phloretin CF delivers a statistically-significant improvement in skin smoothness and general appearance at 1 week post-treatment compared to a lesion not treated with Phloretin CF. (Protocol: a 6-week clinical study, 44 subjects aged 35-65, Fitzpatrick I-III with two similar solar lentigines or actinic keratosis on face or hand. After one treatment with CryoCorrect PrecisionTM device, subjects applied Phloretin CF to one of the two lesions once daily for 6 weeks).

Science & Proof

SkinCeuticals research shows that specific combinations of antioxidants, when effectively formulated, provide superior results to each single antioxidant alone.

Phloretin CF is a triple antioxidant cocktail formulation shown to provide powerful environmental protection due to a synergistic combination of 2% phloretin, 10% pure vitamin C (L-ascorbic acid), and 0.5% ferulic acid. It is formulated under the Duke Antioxidant patent. Vitamin C is a highly-potent antioxidant that, by its structure has difficultly to being effectively absorbed on skin. The Duke Antioxidant patent describes the formulation parameters required for effective delivery of vitamin C to skin:

1) Pure l-ascorbic acid (vitamin C);
2) An acidic pH within the 2.0-3.5 pH range and;
3) A concentration between 10%-20%.

Ingredients

  • 2% phloretin Sourced from apples and the root bark of fruit trees including apple, pear, and grapefruit, the phloretin within this serum neutralises damaging free radicals, helps improve cell turnover, and fades the appearance of discolouration.
  • 10% L-ascorbic acid Lauded for its superior antioxidant benefits, this highly potent form of pure vitamin C neutralises damaging free radicals and protects against oxidative stress while providing visible anti-ageing benefits.
  • 0.5% ferulic acid A plant-based antioxidant, ferulic acid neutralises free radicals and enhances the antioxidant benefits of phloretin and vitamins C and E.

740069 11, AQUA/WATER/EAU, DIPROPYLENE GLYCOL, ALCOHOL DENAT., ASCORBIC ACID, BUTYLENE GLYCOL, TRIETHYL CITRATE, PHLORETIN, FERULIC ACID, D30021/2.

Please be aware that ingredient lists for the products of our brand are updated regularly. Please refer to the ingredient list on your product package for the most up to date list of ingredients to ensure it is suitable to your personal use.

Shipping Notes
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Exchange/Return Notes
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SKU: 31134758391

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Blakely McAllister
Louisville, US
★★★★★ 5
Great toy for our best boys!
Color: Consuela the Cactus - Large, Size: Large Dog
You can never go wrong with BarkBox toys and this was no exception. Our dogs like toys that have squeakers and that they can tear into. This style of toy fits the bill. The design is cute as well. I’ve had this in the house for months and, while it’s definitely seen better days, it’s still intact and they haven’t gotten to the inner layer. (Not for want of trying.) The perfect type of toy for our fur babies.
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Reviewed in the United States on February 10, 2026
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Amazon Customer
Bozeman, US
★★★★★ 5
Survives 7 months so far.
Color: Christmas Consuela, Size: Large Dog
It is still intact after nearly 7 months of constant play. My blue heeler normally destroys toys in just a few weeks. Consuela has exceeded expectations of survival with an extremely chewy, destruction prone dog.
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Reviewed in the United States on June 6, 2026
D
Verified Purchase
D. Thomas
Birmingham, US
★★★★★ 4
Short-lived but much enjoyed as a chew toy
Color: Consuela the Cactus - Large, Size: Large Dog
I bought two of these for my "granddogs" in the size for Large dogs. The German Shepherd-mix stole the one intended for the border collie-mix and had both toys halfway destroyed within a day--I'm pretty sure they didn't survive much longer after that. Much enjoyed! Maybe I should've bought the Extra Large size, because the Large barely fit in her mouth and she wanted to play tug-of-war, so there wasn't much for me to grab onto. Then the border collie wanted in on the action (she's older, so she needed help tugging!) but there wasn't enough material for her to grab onto without accidentally sinking her teeth into me instead.
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Reviewed in the United States on December 9, 2025
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Ryan Davisson
Omaha, US
★★★★★ 5
Best dog toy!
Color: Air Head, Size: Large Dog, Color: Air Head, Size: Large Dog
I got this toy for my dog who loves squeakers not only is it a two in one it actually has three toys inside which I think is amazing!! 10/10 recommend
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Reviewed in the United States on June 11, 2026
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VPBN
Grantham, US
★★★★★ 5
Love all the Barkbox toys
Color: Christmas Consuela, Size: Large Dog
This is our third "Consuela"! Our dogs LOVE these toys, and they are the most durable we can find for our heavy chewers. They really like the ball inside as well. Highly, highly recommend these toys. I won't be buying other toys anymore, just barkbox.
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Reviewed in the United States on March 27, 2026

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