SKU: 4566122984

S23 – Solution, 600MG (20mg/mL)

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Description

S23 – Solution, 600MG (20mg/mL)S23 S23 is an orally available selective androgen receptor modulator (SARM). Originally developed by GTX Inc. as a form of hormonal contraception for men, it exhibits a high affinity for the androgen receptor, with a Ki value of 1. 7 nM. A study published by Jones et al. compared the effectiveness of S23 in both castrated and intact male rats. Effects of S23 on Fertility In castrated male rats, the effective dose of S23 in the prostate was 0. 43 mg

S23

S23 is an orally available selective androgen receptor modulator (SARM). Originally developed by GTX Inc. as a form of hormonal contraception for men, it exhibits a high affinity for the androgen receptor, with a Ki value of 1.7 nM. A study published by Jones et al. compared the effectiveness of S23 in both castrated and intact male rats.

Effects of S23 on Fertility

In castrated male rats, the effective dose of S23 in the prostate was 0.43 mg/day, and 0.079 mg/day in the levator ani muscle. In intact male rats, a dose higher than 0.1 mg/day resulted in a suppression of luteinizing hormone (LH) by more than 50%. This dose corresponded with a reduction in prostate size and an increase in the size of the levator ani muscle.

In a study involving intact male rats subjects treated with both S23 and estradiol benzoate (to maintain sexual behavior), no sperm was found in the testes of four out of the six subjects after 10 weeks. Moreover, none of the six subjects reported a pregnancy. Following treatment, infertility was completely reversible; all subsequent mating trials resulted in pregnancy.

Effects of S23 on Muscle Mass and Body Fat

S23 exhibits effects on muscle mass and body fat that are similar to those of anabolic steroids. Research involving male rats revealed that treatment with S23 led to a reduction in total body weight and fat mass. Rats in this study were also administered estradiol benzoate to maintain sexual behavior. Despite the known muscle loss effects of estrogens, the combination with S23 neutralized this effect, resulting in an increase in muscle mass in the male rats.

Additionally, another study indicated that S23 might be effective against muscle loss caused by prolonged use of glucocorticoids. This research also looked at the effects of S23 on muscle atrophy induced by castration. In both scenarios, muscle loss was observed, but the administration of S23 and testosterone blocked the dexamethasone-induced dephosphorylation of Akt. The findings suggest that S23 could be an effective treatment against muscle loss induced by glucocorticoids.


concentration
20mg/ml.

half-life
12 hours

DISCLAIMER
This material is sold for use in laboratory research only. Terms of sale apply. Not for human consumption, nor for medical, veterinary use. Please use with our DISCLAIMER before ordering.

 

Data sheet

S-23 – Solution, 600mg (20mg/mL)

Application Selective Androgen Receptor Modulator
CAS 1010396-29-8
Molar Mass 416.753 g/mol
Chemical Formula C18H13ClF4N2O3
IUPAC Name (2S)-N-(4-cyano-3-trifluoromethylphenyl)-3-(3-fluoro-4-chlorophenoxy)-2-hydroxy-2-methyl-propanamide
Synonyms UNII-XDK89456WM, 3-(4-cyanophenoxy)-N-(4-cyano-3-trifluoromethylphenyl)-2-hydroxy-2-methylpropionamide, CCTH-methylpropionamide
Storage Room Temperature
Solubility Soluble in PEG400, Ethanol
Organoleptic Profile Clear liquid
Physical Form Solution in PEG400
Specification 20mg/mL ±5%
Terms This material is sold for laboratory research use only. Terms of sale apply. Not for human consumption, nor medical, veterinary, or household uses. Please familiarize yourself with our disclaimer prior to ordering.
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SKU: 4566122984

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4.4 ★★★★★
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E
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E
Carnegie, US
★★★★★ 4
Knot their Omega
Format: Kindle
It took me a day to really get into the book, there is a lot happening in the beginning of the story. I wish there was more of a time frame because I felt like something’s happened quickly but they were farther away than I thought so that was a little confusing to me. I felt like there was so much happening but also not enough. As for the story itself I enjoyed it, it was different than other OV I’ve read. Bring the tissues, you will need them. They guys were great, I wish we saw more of Kai and Kenjis relationship. As for Nate…… IYKYK. I enjoyed this book, my first from this author and look forward to reading about Kamaris story. Book: ⭐️⭐️⭐️⭐️/5 Spice: 🌶️.5/5
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Reviewed in the United States on October 24, 2024
M
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M. Schmitz
Houston, US
★★★★★ 2
Has Potential, Poorly Executed
Format: Kindle
I really really wanted to enjoy this book and was looking forward to reading it. However there were just one too many convoluted plot points, sentences just did not flow nicely at times, and I was left with a lot of confusion on my end. I think it has the bones of being a great story but seems like it was rushed and I had to push myself to finish the last of the book and was left with an unsatisfying ending. It’s definitely different from other omegaverse novels I’ve read but not for good reasons. I really think it could be great but needs some serious tweaking and editing before I’d read it again.
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Reviewed in the United States on February 3, 2025
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Carmen Alicea
Carnegie, US
★★★★★ 5
Secrets, Seduction, and Rockstars!
Format: Kindle
Rockstars, secrets, and off-the-charts chemistry? Sign me up! Cinder Blaze takes us on a rollercoaster of passion and peril with Knot Their Omega. Blair Vesper, a secret Omega masquerading as an Alpha, strikes a risky deal to tour with Blooming Salvation, a band teetering on the edge of chaos. Enter Icarus Morrigan, the enigmatic manager, and his three complicated and irresistibly sexy rockstars: wild Kenji, icy Kaiser, and fiery Nathaniel. This book delivers steamy Omegaverse drama, sizzling slow-burn romance, and just the right dash of angst. The tension between Blair and the band crackles like electricity onstage, while the societal stakes add depth to the spicy dynamics. Short, sharp, and oh-so-sinful Knot Their Omega will have you hooked from the first note!
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Reviewed in the United States on December 9, 2024
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SR
Los Angeles, US
★★★★★ 5
Good start to a series
Format: Kindle
I delayed reading the series for reasons I don’t remember. But my TBR list is huge so I thought I’d take a shot of this and I was pleasantly surprised. I didn’t think the blurb about it was anything special. But it was a very good book. It took some interesting twists and turns. I am so glad the second book is already out. Because I would not have waited patiently. Very slow burn but good storyline. 🔥🔥/5
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Reviewed in the United States on January 3, 2025
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Jammie Clark
Houston, US
★★★★★ 4
A good read
Format: Kindle
Multiple points of view. 3 Alpha men and an Omega male. She is a Beta in training for a new program placing betas in Alpha/Omega packs. Mila is only doing the program for the money to take care of her dad. She wasn't expecting to fall for a pack but when she sees this packs Omega she is done for. There is just something about him. His Alphas are good looking as well. Too bad she is hiding a secret and their government is acting shady. I liked it and can't wait to see where their story goes.
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Reviewed in the United States on November 14, 2023

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