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Description
CD68/SR-D1 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms CD68, CD68 antigen, CD68 molecule, DKFZp686M18236, gp110, LAMP4, macrophage antigen CD68, Macrosialin, SCARD1, scavenger receptor class D, member 1, SRD1T, SR D1 Accession P34810 Amino Acid Sequence Asn22 Ser319, with C terminal Human IgG Fc
Product Specification
| Species | Human |
| Synonyms | CD68, CD68 antigen, CD68 molecule, DKFZp686M18236, gp110, LAMP4, macrophage antigen CD68, Macrosialin, SCARD1, scavenger receptor class D, member 1, SRD1T, SR-D1 |
| Accession | P34810 |
| Amino Acid Sequence | Asn22-Ser319, with C-terminal Human IgG Fc NDCPHKKSATLLPSFTVTPTVTESTGTTSHRTTKSHKTTTHRTTTTGTTSHGPTTATHNPTTTSHGNVTVHPTSNSTATSQGPSTATHSPATTSHGNATVHPTSNSTATSPGFTSSAHPEPPPPSPSPSPTSKETIGDYTWTNGSQPCVHLQAQIQIRVMYTTQGGGEAWGISVLNPNKTKVQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQKVVYLSYMAVEYNVSFPHAAQWTFSAQNASLRDLQAPLGQSFSCSNSSIILSPAVHLDLLSLRLQAAQLPHTGVFGQSFSCPSDRSIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 90-130kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1.nature laboratory investigation pathobiology in focus article Published: 21 November 2016 CD68/macrosialin.
|
Background
CD68 is a highly glycosylated glycoprotein, which has structural similarities with lysosome associated membrane protein (LAMP) and belongs to the LAMP family. Human CD68 contains 354 amino acids (aa), with a 21 aa signal sequence and a 298 aa extracellular domain (ECD), a 25 aa transmembrane domain, and a 10 aa cytoplasmic domain. CD68 is highly expressed by blood monocytes and tissue macrophages. CD68 plays a role in macrophage phagocytosis, intracellular lysosomal metabolism, extracellular cell-cell and cell-pathogen interactions. CD68 can be used alone or in combination with other cell markers of tumor-associated macrophages as a prognostic marker for cancer patient survival, showing good predictive value.
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