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Description
CDH6/Cadherin-6/KCAD Fc Chimera Protein, HumanProduct Specification Species Human Synonyms CDH6, CAD6, KCAD, K cadherin, Cadherin 6 Accession P55285 Amino Acid Sequence Thr19 Ala615, with C terminal Human IgG1 Fc
Product Specification
| Species | Human |
| Synonyms | CDH6, CAD6, KCAD, K-cadherin, Cadherin-6 |
| Accession | P55285 |
| Amino Acid Sequence | Thr19-Ala615, with C-terminal Human IgG1 Fc TLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGAIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 102-112kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Casal J I. et al. (2019) Beyond N-cadherin, relevance of cadherins 5, 6 and 17 in cancer progression and metastasis. Int J Mol Sci. 20(13): E3373. 2、Gugnoni M. et al. (2017) Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy. Oncogene. 36(5): 667-677. 3、Bartolomé R A. et al. (2021) CDH6-activated αIIbβ3 crosstalks with α2β1 to trigger cellular adhesion and invasion in metastatic ovarian and renal cancers. Mol Oncol. 15(7): 1849-1865. |
Background
The CDH6 is also known as Cadherin-6, which belongs to the cell adhesion (CDH) molecules superfamily. The Cadherins comprise a large family of cell adhesion molecules consisting of more than eighty family members and are key regulators of cell adhesion, sorting and invasion. The Cadherins family comprises calcium-dependent transmembrane proteins responsible for cell–cell adhesion during embryogenesis, tissue morphogenesis, differentiation, and maintenance of normal tissue architecture. The CDH6 is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. CDH6 containing five extracellular domains and one cytoplasmic domain that facilitate its interaction with catenin molecules. CDH6 strongly correlated with immunosuppressive cells, including regulatory T cells, monocytes, macrophages, tumor-associated macrophages, and myeloid-derived suppressor cells. CDH6 has been implicated in various processes, including epithelial-mesenchymal transition (EMT), autophagy, and metastasis. The interaction between CDH6 and αIIbβ3 regulates α2β1-mediated adhesion and invasion of ovarian and renal cancer metastatic cells and constitutes a therapeutic target of broad potential for treating metastatic progression.
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4.9 ★★★★★
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Product Reviews
★★★★★ 3
Size up
While I like the concept, it’s not true to size. I cut the tag off thinking this fit well, as I wear 38G in most HSIA bras, I found that throughout the day this rode up and gave me “quad-breast.” It also broke the skin on my back where the anti-slip rubber was on the band. It has potential, maybe if you size up with band and cup.
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Reviewed in the United States on May 7, 2026
★★★★★ 5
Stylish, spacious, and perfect for travel
Color: Upgrade-apricot, Size: 16 Inch
This backpack is well-made and very practical for travel. It offers plenty of space, well-organized compartments, and feels comfortable to carry even for long periods. The design is sleek and modern, making it suitable for both travel and daily use. Great quality for the price.
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Reviewed in the United States on January 31, 2026
★★★★★ 5
Great quality and very practical
Color: Upgrade-apricot, Size: 16 Inch, Color: Upgrade-apricot, Size: 16 Inch
I’m very happy with this backpack. The material feels sturdy and well-made, with a smooth finish that looks elegant and easy to clean. The size is perfect—not too big or bulky, but still spacious enough to carry everything I need. The stitching and zippers feel strong and reliable.
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Reviewed in the United States on January 20, 2026
★★★★★ 5
Great quality for the price!
Color: Upgrade-darkgreen, Size: 16 Inch
Great backpack with lots of pockets. Due to the price I was worried about the quality, but I have used it for a few months now and it's holding up great. Love the color and would recommend!
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Reviewed in the United States on May 1, 2026
★★★★★ 4
Good for travel
Color: Regular-black, Size: 16 Inch
Good looking backpack for travel. Compact and good quality.
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Reviewed in the United States on July 29, 2025