SKU: 86515029398

S-RMab® c-Met Recombinant Rabbit mAb (SDT-009-7H0L0)

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Description

S-RMab® c-Met Recombinant Rabbit mAb (SDT-009-7H0L0)Product Specification Host Rabbit Antigen c Met Synonyms HGF SF receptor, Proto oncogene c Met, Scatter factor receptor (SF receptor), Tyrosine protein kinase Met Immunogen Synthetic Peptide Location Cytoplasm, Membrane Accession P08581 Clone Number SDT 009 7H0L0 Antibody Type Rabbit mAb Isotype IgG Application WB, IHC P Reactivity Hu Purification Protein A Concentration 2mg ml Molecular Weight 140kDa,170kDa Conjugation Unconjugated Physical

Product Specification


Host Rabbit
Antigen c-Met
Synonyms HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor (SF receptor), Tyrosine-protein kinase Met
Immunogen Synthetic Peptide
Location Cytoplasm, Membrane
Accession P08581
Clone Number SDT-009-7H0L0
Antibody Type Rabbit mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Purification Protein A
Concentration 2mg/ml
Molecular Weight

140kDa,170kDa

Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
IHC-P 1:300
WB 1:40000

Background

c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGFR), is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. MET is a single pass tyrosine kinase receptor essential for embryonic development, organogenesis and wound healing. Hepatocyte growth factor/Scatter Factor (HGF/SF) and its splicing isoform (NK1, NK2) are the only known ligands of the MET receptor. MET is normally expressed by cells of epithelial origin, while expression of HGF/SF is restricted to cells of mesenchymal origin. When HGF/SF binds its cognate receptor MET it induces its dimerization through a not yet completely understood mechanism leading to its activation. Abnormal MET activation in cancer correlates with poor prognosis, where aberrantly active MET triggers tumor growth, formation of new blood vessels (angiogenesis) that supply the tumor with nutrients, and cancer spread to other organs (metastasis). MET is deregulated in many types of human malignancies, including cancers of kidney, liver, stomach, breast, and brain. Normally, only stem cells and progenitor cells express MET, which allows these cells to grow invasively in order to generate new tissues in an embryo or regenerate damaged tissues in an adult. However, cancer stem cells are thought to hijack the ability of normal stem cells to express MET, and thus become the cause of cancer persistence and spread to other sites in the body. Both the overexpression of Met/HGFR, as well as its autocrine activation by co-expression of its hepatocyte growth factor ligand, have been implicated in oncogenesis.

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SKU: 86515029398

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4.2 ★★★★★
Based on 8 reviews
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Verified Purchase
Dana K.
Fort Morgan, US
★★★★★ 5
I highly recommend this pillow, it’s great for someone with neck or back problems.
Size: Queen (Pack of 1), Size: Queen (Pack of 1)
I absolutely love this pillow! When it says it’s adjustable it definitely means that. When you first get it, it’s hard to believe that it’s going to be anything but put it in the dryer for a few minutes and it becomes so large. You will definitely have to remove some of the stuffing unless you like a really large fluffy pillow. The stuffing is high-quality and once it has been put into the dryer it becomes a fibrous type material that can be fluffed over and over and go back to the same size. It seems to be a high-quality cover on the outer portion and is thick and has a slight cooling affect. It has a separate cover on the inner portion covering the foam stuffing. I ordered this because I have neck problems and it has been super comfortable for me because I’m able to adjust it multiple times depending on my needs for the particular night when I lay down. Having the extra stuffing means that if the pillow does happen to go flat I can always add the extra that I took out when I received it. It did have a slight odor when it first came, but after putting it in the dryer, it went away immediately. I do think that’s only due to the plastic that it’s shipped in not anything with the pillow. I think this pillow is well worth it price and I would highly recommend it for anyone that is a side or back sleeper or has any type of neck problems.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 3, 2026
C
Verified Purchase
Caitlyn
Port Orchard, US
★★★★★ 5
Amazing!
Size: King (Pack of 1)
Such a great pillow I’m buying another one! You can add or subtract stuffing to your liking. It’s really nice quality, quilted and soft. Best pillow ever. Super comfy and great sleep. Pretty firm with all the stuffing. Perfect the way it came with stuffing on the side. My husband loves it and now I want one.
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Reviewed in the United States on May 15, 2026
A
Verified Purchase
Alli
Omaha, US
★★★★★ 5
Totally worth the money
Size: King (Pack of 1), Size: King (Pack of 1)
Right off the bat, the packaging is absolutely adorable and felt like I was buying a premium product. I love that this pillow is adjustable and as a side sleeper, I needed a pillow that is both firm and supportive of my neck. This hits all the boxes. We will be buying more of these for our bed!
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Reviewed in the United States on June 1, 2026
A
Verified Purchase
Artem
Fort Morgan, US
★★★★★ 5
Super Comfortable and Cooling Pillow!
Color: Blue, Size: Standard
I’ve been using this pillow for a few days now and I really love it! The cooling gel side feels amazing and stays cool during the night. The memory foam is soft but still supportive for my neck and shoulders. I wake up feeling much more rested and without neck stiffness. The quality is excellent and the cover is very soft and easy to clean. Definitely worth the purchase!
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Reviewed in the United States on May 10, 2026
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Verified Purchase
Johanny Batista
Battle Creek, US
★★★★★ 5
Loved it ♥️♥️♥️
Color: Blue, Size: Standard
Very comfortable and cool for sleeping. The memory foam provides excellent neck support and helps you rest better throughout the night. I loved the cooling cover because it truly feels cool and soft. Plus, it is easy to wash and maintains its high quality. Highly recommended.
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Reviewed in the United States on May 29, 2026

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