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Description
Human TrkB , His tagProduct Specification Species Human Synonyms GP145 TrkB (Trk B), Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin related kinase B, NTRK2 Accession Q16620 Amino Acid Sequence Protein sequence(Q16620, Trp230 His430, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | GP145-TrkB (Trk-B), Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, Tropomyosin-related kinase B, NTRK2 |
| Accession | Q16620 |
| Amino Acid Sequence | Protein sequence(Q16620, Trp230-His430, with C-10*His) WDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHGGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:24kDa Actual: 35-45kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), and neurotrophin-3 (NT-3). Although originally identified as an oncogenic fusion in 1982, only recently has there been a renewed interest in the Trk family as it relates to its role in human cancers because of the identification of NTRK1 (TrkA), NTRK2 (TrkB) and NTRK3 (TrkC) gene fusions and other oncogenic alterations in a number of tumor types. A number of Trk inhibitors are in clinical trials and have shown early promise in shrinking human tumors. TrkB and its ligand BDNF have been associated to both normal brain function and in the pathology and progression of Alzheimer’s disease (AD) and other neurodegenerative disorders.
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4.3 ★★★★★
Based on 10 reviews
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Product Reviews
★★★★★ 3
less than 24 hours :/
Color: Grey Bear - Large, Color: Grey Bear - Large
smaller than i expected but had a strong interior that i was pleasantly surprised with. my lil lady very much enjoyed it, however it lasted less than 24 hours before the poor toy was skinned alive :( she loves plushies and she’s obsessed w his skin after tearing him apart. it does have a solid rubber interior that is still good as a toy, however i was hoping its skin would stay on longer than a day :( overall decent toy, 3 stars for being destroyed so quickly. wouldn’t recommend for strong chewers
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Reviewed in the United States on August 7, 2025
★★★★★ 5
Lasts long
Color: Panda Bear - Large
Perfect for super chewer dogs.
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Reviewed in the United States on May 14, 2026
★★★★★ 4
Dachshund said “did I hear indestructible‽ Hold my ball”
Color: Grey Bear - Large
My 15lb Dachshund took this toy as a personal challenge.
He heard me tell his human brother that it’s indestructible on the inside and said “hold my ball” promptly proceeding to schmurder the textile aspect of this adorable toy.
I’d say it took him a total of 23 1/2 minutes to get to the center of this tootsie pop. I’m not even mad tho bc he had no interest in actually ingesting the outer part, and is totally into the inner toy, which is, for him, literally indestructible. It’s solid rubber, has a wild and fun bounce to it on multiple surfaces.
Zodiac rates the squeak 10/10. It’s great especially for when I’m on a call or talking to someone in real life and can’t immediately throw said toy or pay complete attention to him.
In conclusion:
Your dog will probably love it, ((suggest to just keep an eye on them during the schmurder process and make sure you grab all the pieces that come off so none are swallowed))
Depending on your tolerance for squeaker pitch and frequency of squeak, it's a 4/10 in annoyance mostly bc it’s not a long drawn out squeak ((I can not tolerate those toys, they get “lost on top on my fridge” until I get up the courage to throw them out without him seeing)), it’s quick and requires a bit of effort to produce the sound however it’s a very high pitch squeak so it’s all up to your preference. I personally try to buy toys I can tolerate my dog loving on bc when he gets a new toy, it’s his favorite thing for a long time, like, it sleeps on the bed with us for the first month.
Hope your fur child loves this as much as mine did.
Not sure I’ll do the whole two in one toy thing again only he got through it so fast.
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Reviewed in the United States on December 25, 2025
★★★★★ 5
LOVE BARK TOYS!!!
Color: Rad Herring - Medium
I got this toy for my 1yr old Husky/Heeler/(possibly)GSD (approx 42lbs) mix when she came to our home mid/late October of 2025 and the toy lasted until December 3rd 2025 when we had to assist her with opening the fabric to get the toy on the inside.
It was a great fun toy for her and the inside toys still is and she loves playing with it. The durability of both the outside and inside toys are great for super chewers! I was glad there was no stuffing because I had gotten her a plush toy once before and she destroyed that immediately. The fabric on this was durable enough to withstand her chewing yet soft enough that it didn’t hurt her teeth. The colors were vibrant and fun for both toys even though wear and tear kinda took some of the fabric color away. I would definitely buy this again once the inside toy is no longer safe for her, especially since the size was perfect for her too.
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Reviewed in the United States on January 12, 2026
★★★★★ 5
Good ball for strong chewers
Color: Cheeze Brawl - Large, Color: Cheeze Brawl - Large
My dog loves this ball except the outside fur gets gross really quickly. However, it’s easy to cutoff and underneath is a strong squeaky ball. It’s like two gifts in one. He’s a very heavy chewer and the ball lasts quite a bit.
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Reviewed in the United States on December 31, 2025