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Description
PTEN Recombinant Rabbit mAb (SDT-R074)Product Specification Host Rabbit Antigen PTEN Synonyms MMAC1, TEP1 Immunogen N A Location Cytoplasm, Nucleus Accession P60484 Clone Number SDT R074 Antibody Type Rabbit mAb Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as supplied
Product Specification
| Host | Rabbit |
| Antigen | PTEN |
| Synonyms | MMAC1, TEP1 |
| Immunogen | N/A |
| Location | Cytoplasm, Nucleus |
| Accession | P60484 |
| Clone Number | SDT-R074 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500-1:1000 | null |
| WB | 1:1000 | null |
| ICFCM | 1:500 | null |
| ICC | 1:500 | null |
Background
PTEN is a dual-specificity phosphatase at two levels. First, PTEN has been shown to dephosphorylate protein substrates on serine/threonine and tyrosine residues, thus acting as a dual-specificity protein phosphatase. One example is the tyrosine dephosphorylation of focal adhesion kinase (FAK) to inhibit cell spreading. Second, PTEN also dephosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3) to phosphatidylinositol 4,5-bisphosphate (PIP2) — hence, PTEN is also a dual-specificity phosphatase in the sense that it dephosphorylates lipid substrates in addition to protein substrates.
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