SKU: 11089664357

EphA10 His Tag Protein, Human

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Description

EphA10 His Tag Protein, HumanProduct Specification Species Human Antigen EphA10 Synonyms Ephrin type A receptor 10, EPHA10 Accession Q5JZY3 Amino Acid Sequence Glu34 Ala565, with C terminal 10*His

Product Specification


Species Human
Antigen EphA10
Synonyms Ephrin type-A receptor 10, EPHA10
Accession Q5JZY3
Amino Acid Sequence

Glu34-Ala565, with C-terminal 10*His EEVILLDSKASQAELGWTALPSNGWEEISGVDEHDRPIRTYQVCNVLEPNQDNWLQTGWISRGRGQRIFVELQFTLRDCSSIPGAAGTCKETFNVYYLETEADLGRGRPRLGGSRPRKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSRRGFHLAFQDVGACVALVSVRVYYKQCRATVRGLATFPATAAESAFSTLVEVAGTCVAHSEGEPGSPPRMHCGADGEWLVPVGRCSCSAGFQERGDFCEACPPGFYKVSPRRPLCSPCPEHSRALENASTFCVCQDSYARSPTDPPSASCTRPPSAPRDLQYSLSRSPLVLRLRWLPPADSGGRSDVTYSLLCLRCGREGPAGACEPCGPRVAFLPRQAGLRERAATLLHLRPGARYTVRVAALNGVSGPAAAAGTTYAQVTVSTGPGAPWEEDEIRRDRVEPQSVSLSWREPIPAGAPGANDTEYEIRYYEKGQSEQTYSMVKTGAPTVTVTNLKPATRYVFQIRAASPGPSWEAQSFNPSIEVQTLGEAASGSRDQSPAGGGSGGGSHHHHHHHHHH
Expression System HEK293
Molecular Weight 68-90kDa
Purity ＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Jing Peng, Danhua Zhang. Coexpression of EphA10 and Gli3 promotes breast cancer cell proliferation, invasion and migration, J Investig Med. 2021 Aug;69(6):1215-1221. Epub 2021 May 14.
2. Kullander K., Klein R. Mechanisms and functions of Eph and ephrin signalling. Nat. Rev. Mol. Cell Biol. 2002;3:475-486.
3. Dodelet V.C., Pasquale E.B. Eph receptors and ephrin ligands: Embryogenesis to tumorigenesis. Oncogene. 2000;19:5614-5619.
4. Aasheim H.C., Patzke S., Hjorthaug H.S., Finne E.F. Characterization of a novel Eph receptor tyrosine kinase, EphA10, expressed in testis. Biochim. Biophys. Acta. 2005;1723:1-7.
5. Nagano K., Maeda Y., Kanasaki S., Watanabe T., Yamashita T., Inoue M., Higashisaka K., Yoshioka Y., Abe Y., Mukai Y., Kamada H., Tsutsumi Y., Tsunoda S. Ephrin receptor A10 is a promising drug target potentially useful for breast cancers including triple negative breast cancers. J. Control Release. 2014;189:72-79.

Background

Ephrin receptors (Ephs), the largest subfamily of receptor tyrosine kinases, are known to modulate cell–cell signaling by interacting with cells’ membrane-bound ephrin ligands on neighboring cells, thereby regulating tissue organization, vascular development, and progression of many diseases including cancer. Ephrin receptor A10 (EphA10), a member of the Eph subfamily, is not expressed in normal human adult tissue except in the testis. The Eph/ephrin signaling mediates cell-cell interaction and contributes to the tumorigenesis, angiogenesis and metastasis in many cancers. EphA10 expression is common in malignant cells across histology of various tumors and has been associated with poor prognosis in patients with breast, prostate, and gallbladder cancers.

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SKU: 11089664357

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4.6 ★★★★★
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Verified Purchase
Dustin Felton
West Palm Beach, US
★★★★★ 5
Siless Hybrid 3-in-1 - Far Exceeded my Expectations!!!
Model: SLH20025
I recently installed the Siless Hybrid 3-in-1 sound deadening mat in my vehicle, and I’m genuinely impressed. For just $80 for 25 square feet, this product delivers performance that rivals materials costing twice as much — and with far less hassle. If you're on the fence......Just buy it! You will not be disappointed. Easy to Install: Unlike traditional sound deadening products that are stiff, sharp, and temperature-sensitive, this mat is soft, flexible, and easy to work with. I cut it cleanly with regular scissors and pressed it into tight spaces using just my fingers, so if in you don't have a roller or install tool, a good pair of scissors and your hands can get the job done. With other brands like Dynamat, the aluminum layer often leaves micro cuts on your hands and tears up your fingertips, but Siless does not due the acoustic layer being on top and above the aluminum layer that holds the butyl layer. So, it's very easy on your hands. Even in cooler temperatures (around 50°F), I had no trouble applying it but it goes on better heated. If warm outside, I would leave the entire box out in the sun for at least 30 minutes when it's warm or heats it's very pliable and easy to mold. Make sure its where you want it because once applied it's not ever falling off. and it became even more pliable and easy to mold. No heat gun, no mess — just straightforward application. I installed 40–50 square feet throughout the interior, covering everything except the headliner and the flooring forward of the rear seat. The difference in cabin noise is astonishing. I can turn my radio up concert loud with gut-punching bass, and from outside the car, it sounds like a factory sound system at mid volume. I was blown away by how well it contains sound — both inside out and outside in. My exhaust is pretty aggressive and now is barely audible from inside the cabin. While driving, it almost sounds like a stock factory setup. The Siless matting actually changed the driving experience and feels refined. If you're skeptical about sound deadening gimmicks, I get it, but this is the first product I've used and when I needed more, I went Stright to the 3 in 1 Hybrid matting and purchased it again. I love researching before buying and that's very uncommon for me to do. Note: Proper installation is key, and it does take time and patience. But if installed correctly and in the right places, it works better previously used from paint-on sound deadening to Dynamat. Update Nov, 2025 After using it this in 4 separate vehicles now. I feel the Siless’s 3 in 1 Hybrid has nailed it for best budget deadener that is better than dynamat extreme in performance and installation Protip: buy a roll of 2-3” aluminum tape and tape the seams. After trimming the edges tend to very sticky between the panels. I ran a strip of aluminum tape over the seems to create a better seal and true moisture I used it on four vehicles now and have I have not been paid to review and purchased every order myself. 3 in 1 Hybrid deadener by Siless is the best all around easy to apply sound deadner period!
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Reviewed in the United States on September 29, 2025
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Verified Purchase
Tee & Cee
Los Angeles, US
★★★★★ 5
Top quality
Model: SLH20025
This Siless Hybrid 3-in-1 sound deadening mat is easy to work with and feels high-quality. The butyl material is thick and pliable, making it simple to cut and fit into doors, floors, or panels. After installation, road noise and vibrations are noticeably reduced, and it also seems to improve the overall cabin feel. No bad smell. At 25 sq ft per roll, it’s a good value for anyone looking to dampen noise and improve car acoustics. Overall, a solid, effective option for automotive soundproofing. Used on a Fiesta ST.
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Reviewed in the United States on February 15, 2026
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Verified Purchase
Andy
Draper, US
★★★★★ 5
Made a big improvement in cabin noise—highly recommend
Model: SLH20025
Siless Hybrid made a huge difference in reducing noise in the floor of my truck cabin. In some areas, there was basically just bare sheet metal between the inside and outside, so adding this really helped the truck feel more solid and noticeably quieter on the road. I used Kilmat on the doors, and honestly I wish I had used Siless Hybrid there too, but it was too late by the time I realized the difference. This material is very sticky, easy to cut, and simple to apply, which made the install pretty smooth. Just a heads-up: the tacky side gets messy and will bond to clothing really easily, so be careful during installation. Overall, I’d definitely buy it again—great product with real results.
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Reviewed in the United States on December 2, 2025
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Verified Purchase
AmazinFrank
Fort Morgan, US
★★★★★ 5
Very good product at a fair price
Model: SLH20025
Very good sound deadener and heat shield, it is a bit sticky to work with, but easy to shape and cut
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Reviewed in the United States on April 19, 2026
E
Verified Purchase
Eric Caldeira
Carnegie, US
★★★★★ 5
I wish I had Siless 20 years ago!!!
Model: SLH20025, Model: SLH20025
I have installed all kinds of insulation in vehicles over many years. I only needed to purchase 2 boxes to complete the entire interior siding of my 2025 chevy express, what a great value! I wanted to insulate my locksmith van for sound and heat. The sound reduction virtually eliminated the road noise. These panels also look amazing. It got up to 110F in the sun with the doors closed. After adding Siless insulation the temperature maxed out at 97F. That is a massive difference. Plus, I didn't even finish with the roof before testing. Siless Hybrid 3in1 was extremely easy to cut and adhere onto metal panels. I'm impressed with the quality of the individual panels and the adhesive is not toxic smelling compared to some others. My favorite thing about these panels is you can actually take them off and readjust them before they finally stick and they do not leave any black residue behind when you pull them up to adjust them. All I needed was a heat gun, knife and a roller to complete this job. The size of each panel is perfect, you can handle them with ease. I probably won't need your product again for a while, but when I do I will definitely be back.
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Reviewed in the United States on September 21, 2025

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