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Description
TNF-β Protein, HumanProduct Specification Species Human Synonyms Lymphotoxin Alpha; LT Alpha; TNF Beta; Tumor Necrosis Factor Ligand Superfamily Member 1; LTA; TNFB; TNFSF1 Accession P01374 Amino Acid Sequence Leu35 Leu205 Expression System E. coli Molecular Weight 18. 7 kDa (Reducing) Purity >95% by SDS PAGE and HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris, 50mM NaCl, pH8. 0 Reconstitution
Product Specification
| Species | Human |
| Synonyms | Lymphotoxin-Alpha; LT-Alpha; TNF-Beta; Tumor Necrosis Factor Ligand Superfamily Member 1; LTA; TNFB; TNFSF1 |
| Accession | P01374 |
| Amino Acid Sequence | Leu35-Leu205 |
| Expression System | E.coli |
| Molecular Weight |
18.7 kDa (Reducing)
|
| Purity | >95% by SDS-PAGE and HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 50mM NaCl, pH8.0 |
| Reconstitution |
|
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1. Arthritis Res Ther. 2013;15(6): R202. 2. Dev Comp Immunol. 2021 Feb: 115:103884. Epub 2020 Oct 9. |
Background
TNF-β, also called lymphotoxin-α (LT-α), is expressed by a variety of cells, including T cells, B cells and natural killer (NK) cells. It can be secreted and, like TNF-α, binds with high affinity to TNF receptors 1 and 2 (TNFR-1 and TNFR-2), and it is transiently expressed on the cell surfaces of activated B and T cells, where it forms a complex with LT-β as an LTα1β2 heterotrimer. TNF-β can activate many kinds of immune cells, and prompt secretion of other cytokines for infection clearance. For some physiological processes, TNF and LTαβ work together as components of an integrated signaling network that is defined in part by communal sharing of receptors and ligands.
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