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Ships within 48 hours · Estimated delivery Aug 30 - Sep 4
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For Your Every Summer RSVP, with Code: SUMMER15
Description
Biotin Mouse Anti-Human CD15 Antibody (S-R463)Product Specification Host Mouse Antigen CD15 Synonyms Sialyl LewisX (sLeX); SSEA1 Location Membrane Accession P22083 Clone Number S R463 Antibody Type Mouse mAb Isotype IgM Application FCM Reactivity Hu Positive Sample human Peripheral Blood cells Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution,
Product Specification
| Host | Mouse |
| Antigen | CD15 |
| Synonyms | Sialyl LewisX (sLeX); SSEA1 |
| Location | Membrane |
| Accession | P22083 |
| Clone Number | S-R463 |
| Antibody Type | Mouse mAb |
| Isotype | IgM |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human Peripheral Blood cells |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD15, also known as Lewis X or SSEA-1, is a fucosylated carbohydrate antigen found on the surface of various cells. It is a complex cluster of cell surface glycoproteins and glycolipids with a common terminal pentasaccharide. CD15 plays a significant role in cell adhesion and migration, particularly in immune responses and development. It is expressed on most terminally differentiated myeloid cells, including granulocytes, eosinophils, and monocytes/macrophages, but not on hematopoietic progenitor cells. In addition, CD15 is found in various epithelia and neural tissues. In cancer, CD15 is present on the membrane proteins of several types of cancer cells, such as renal, prostate, and breast cancer cells. It interacts with selectins to facilitate cancer cell adhesion to endothelial cells, promoting metastasis. Therefore, CD15 has potential as a therapeutic target and prognostic marker in cancer treatment.
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