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Description
Atg7 Recombinant Rabbit mAb (S-R302)Product Specification Host Rabbit Antigen ATG7 Synonyms Ubiquitin like modifier activating enzyme ATG7, ATG12 activating enzyme E1 ATG7, Autophagy related protein 7 (APG7 like; hAGP7), Ubiquitin activating enzyme E1 like protein, APG7L Location Cytoplasm Accession O95352 Clone Number S R302 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | ATG7 |
| Synonyms | Ubiquitin-like modifier-activating enzyme ATG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7 (APG7-like; hAGP7), Ubiquitin-activating enzyme E1-like protein, APG7L |
| Location | Cytoplasm |
| Accession | O95352 |
| Clone Number | S-R302 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC-P | 1:500 | null |
| IP | 1:50 | null |
Background
ATG 7, present in both plant and animal genomes, acts as an essential protein for cell degradation and its recycling. The sequence associates with the ubiquitin- proteasome system, UPS, required for the unique development of an autophagosomal membrane and fusion within cells. During the initiation of autophagy, ATG7 acts like an E-1 enzyme for ubiquitin-like proteins (UBL) such as ATG12 and ATG8. ATG7 helps these UBL proteins in targeting their molecule by binding to them and activating their transfer to an E-2 enzyme. ATG7's role in both of these autophagy-specific UBL systems makes it an essential regulator of autophagosome assembly.
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Exchange/Return Notes
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