SKU: 14107086715

Mouse Anti-Human CD268 (BAFF Receptor) Antibody (S-4520)

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Description

Mouse Anti-Human CD268 (BAFF Receptor) Antibody (S-4520)Product Specification Host Mouse Antigen CD268 (BAFF Receptor) Synonyms Tumor necrosis factor receptor superfamily member 13C; B cell activating factor receptor; BAFF receptor (BAFF R); BLyS receptor 3; BAFFR; BR3; TNFRSF13C Location Membrane Accession Q96RJ3 Clone Number S 4520 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical

Product Specification


Host Mouse
Antigen CD268 (BAFF Receptor)
Synonyms Tumor necrosis factor receptor superfamily member 13C; B-cell-activating factor receptor; BAFF receptor (BAFF-R); BLyS receptor 3; BAFFR; BR3; TNFRSF13C
Location Membrane
Accession Q96RJ3
Clone Number S-4520
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein G
Concentration 2 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1:200 Hu

Background

CD268, also known as the B-cell Activating Factor Receptor (BAFF-R or BR3), is a type III transmembrane protein belonging to the tumor necrosis factor receptor (TNFR) superfamily that plays a pivotal role in B lymphocyte biology by serving as the primary high-affinity receptor for BAFF (BLyS). Predominantly expressed on the surface of mature and transitional B cells, CD268 is essential for B cell survival, maturation from the transitional to the follicular stage, and the maintenance of peripheral B cell homeostasis through the activation of key signaling pathways such as NF-κB (both canonical and non-canonical), PI3K/Akt, and MAPK. Upon binding to its ligand BAFF, CD268 prevents apoptosis by upregulating anti-apoptotic proteins like Bcl-2 and Mcl-1, thereby ensuring the longevity of the B cell pool; conversely, defects or deficiencies in CD268 signaling lead to a severe reduction in mature B cell numbers and impaired humoral immunity. Due to its critical function in B cell survival, CD268 is a significant therapeutic target in autoimmune diseases characterized by B cell hyperactivity, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, as well as in B cell malignancies, where blocking this receptor can effectively induce the depletion of pathogenic or malignant B cells.

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SKU: 14107086715

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4.4 ★★★★★
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K
Verified Purchase
KarenMarie
Draper, US
★★★★★ 5
They love the cool characters
Format: Paperback
My summer cap kids love this book...
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 14, 2025
S
Verified Purchase
stinks
Charlottesville, US
★★★★★ 5
Perfect for End of School Year!
Format: Paperback
I purchased this book because I was chosen as the last mystery reader before summer break for my daughter’s class. The book was sweet, appropriate, and nostalgic. The kids and teacher really enjoyed!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 20, 2024
O
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Onceuponatime
Bozeman, US
★★★★★ 5
So sweet and nostalgic!
Format: Hardcover
Love, love, love this book as an adult. What great memories it brings back, so many specific ones are included. My grandkids love it too, "That's just what we do!", they say excitedly.
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Reviewed in the United States on May 31, 2024
L
Verified Purchase
Lisa Plancich
Lexington, US
★★★★★ 5
Everyone Can Use A Little Assistance With Manners
Format: Hardcover
"Manners Can Be Fun" covers basics like introductions, please and thank you, being responsible in the home you live in and table manners. It's the illustrations, however, which get the point across and hit the reader over the head. No matter your age, the cute drawings really let one see what others experience when you behave badly. The basics of what's important in life are put into perspective and appreciated all over again. Playing, saying "hello" and so many other topics pertinent to etiquette and consideration are placed on Mr. Leaf's pages in quick, precise prose which encourage action. Munro Leaf's description of The Noisey's, The Pigs, Me First, Whineys, Smash, Rip, Ruin and others assist young and old of what to do around others and what not to do. It's basic, it's short and sweet, it's truly a classic. Like all classics, "Manners Can Be Fun" has not gone out of style. Many thanks to Universe Publishing for placing this wonderful book back on the shelves and into our hands.
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Reviewed in the United States on January 29, 2010
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Texas
Draper, US
★★★★★ 5
A classic for the kids in your family.
Format: Hardcover
This is a classic book of manners written for youngsters. I had a copy a copy when I was a child, read it to my children, gave it to my grandchildren and purchased this copy for my great grandchildren. Necessary lessons are presented simply with illustrations one won’t forget. The lesson I remember most is this: “Be kind to animals. They have feelings too.” Most highly recommend.
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Reviewed in the United States on August 16, 2022

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