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Description
CDKN2A/p16 INK4A Recombinant Rabbit mAb (S-4676)Product Specification Host Rabbit Antigen CDKN2A p16 INK4A Synonyms Tumor suppressor ARF; Alternative reading frame (ARF); Cyclin dependent kinase inhibitor 2AImported; p14ARF; CDKN2; MLM; CDKN2A Location Nucleus, Mitochondrion Accession Q8N726 Clone Number S 4676 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample HeLa, HEK 293, Saos 2 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | CDKN2A/p16 INK4A |
| Synonyms | Tumor suppressor ARF; Alternative reading frame (ARF); Cyclin-dependent kinase inhibitor 2AImported; p14ARF; CDKN2; MLM; CDKN2A |
| Location | Nucleus, Mitochondrion |
| Accession | Q8N726 |
| Clone Number | S-4676 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | HeLa, HEK-293, Saos-2 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
Background
CDKN2A/p16INK4A is a critical tumor suppressor protein encoded by the CDKN2A gene that functions as a key negative regulator of the cell cycle by specifically inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6), thereby preventing the phosphorylation of the retinoblastoma protein (Rb) and arresting cell progression from the G1 to the S phase to curb uncontrolled proliferation. Often referred to as p16, this protein acts as a vital checkpoint against oncogenic transformation, and its loss of function through genetic deletion, mutation, or epigenetic silencing is a hallmark event in numerous human cancers, including melanoma, pancreatic ductal adenocarcinoma, and glioblastoma; conversely, its overexpression is frequently observed in cells undergoing senescence or in HPV-associated malignancies where it serves as a reliable diagnostic biomarker due to the disruption of the Rb pathway by viral oncoproteins, making p16INK4A not only a fundamental component of cellular defense mechanisms but also a significant target for therapeutic strategies and prognostic assessments in oncology.
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