SKU: 15757479952

Haptoglobin Recombinant Rabbit mAb (SDT-339-105)

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Description

Haptoglobin Recombinant Rabbit mAb (SDT-339-105)Product Specification Host Rabbit Antigen Haptoglobin Immunogen Recombinant Protein Accession P00738 Clone Number SDT 339 105 Antibody Type Rabbit mAb Application Sandwich ELISA Reactivity Hu Cross Reactivity Does not recognize Hemoglobin Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt

Product Specification


Host Rabbit
Antigen Haptoglobin
Immunogen Recombinant Protein
Accession P00738
Clone Number SDT-339-105
Antibody Type Rabbit mAb
Application Sandwich ELISA
Reactivity Hu
Cross Reactivity Does not recognize Hemoglobin
Purification Protein A
Concentration 2 mg/ml
Purity >95% by HPLC
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer PBS pH7.4, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
Sandwich ELISA N/A

Background

Haptoglobin (abbreviated as Hp) is the protein that in humans is encoded by the HP gene. In blood plasma, haptoglobin binds with high affinity to free hemoglobin released from erythrocytes, and thereby inhibits its deleterious oxidative activity. Compared to Hp, hemopexin binds to free heme. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen). In clinical settings, the haptoglobin assay is used to screen for and monitor intravascular hemolytic anemia. In intravascular hemolysis, free hemoglobin will be released into circulation and hence haptoglobin will bind the hemoglobin. This causes a decline in haptoglobin levels. Haptoglobin, in its simplest form, consists of two alpha and two beta chains, connected by disulfide bridges. The chains originate from a common precursor protein, which is proteolytically cleaved during protein synthesis. Hp exists in two allelic forms in the human population, so-called Hp1 and Hp2, the latter one having arisen due to the partial duplication of Hp1 gene. Three genotypes of Hp, therefore, are found in humans: Hp1-1, Hp2-1, and Hp2-2. Hp of different genotypes have been shown to bind hemoglobin with different affinities, with Hp2-2 being the weakest binder. Hemoglobin that has been released into the blood plasma by damaged red blood cells has harmful effects. The HP gene encodes a preproprotein that is processed to yield both alpha and beta chains, which subsequently combines as a tetramer to produce haptoglobin. Haptoglobin functions to bind the free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Most attention has been paid to determining haptoglobin phenotype as a genetic fingerprint used in forensic medicine. More recently, several functional differences between haptoglobin phenotypes have been demonstrated that appear to have important biological and clinical consequences. Haptoglobin polymorphism is associated with the prevalence and clinical evolution of many inflammatory diseases, including infections, atherosclerosis, and autoimmune disorders. These effects are explained by a phenotype-dependent modulation of oxidative stress and prostaglandin synthesis. Recent evidence is growing that haptoglobin is involved in the immune response as well. The strong genetic pressure favoring the 2-2 phenotype suggests an important role of haptoglobin in human pathology.

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SKU: 15757479952

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Sarah A
Waukegan, US
★★★★★ 5
Great fun for my small pup
Color: Egg Balls
My 15lb Pom loves anything that sqweeks so these little eggs are perfect for him. They are fun to throw since they bounce in all different directions. Considering how many you get it's worth purchasing
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Reviewed in the United States on January 31, 2026
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Casandra L.
Birmingham, US
★★★★★ 5
dogs have fun with them
Color: Smile Face Balls
They are a cute product. Do not give to large dogs. Made for tiny breeds. I dog sit and the dogs who are allowed to play with them go nuts when I get them out and give a sqeeze. The toys are holding up well too.
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Reviewed in the United States on April 22, 2026
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J_B_Cran
Houston, US
★★★★★ 5
Love.
Color: Pig Balls
My frenchies love these and large enough not to worry about choking. Also the squeaker lasts longer than most of their latex toys so good or bad, I think it’s good.
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Reviewed in the United States on April 21, 2026
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vvickib54
Birmingham, US
★★★★★ 5
Puppy Favorite!
Color: Funny Face Balls
Just the right size for a cocker puppy to fit in her mouth (3 mos. old) and squeak. She will do this indefinitely if I let her, lol! Seems to be very satisfying for her. I can only take so much of it but she loves them. Also bounces erratically when you toss it which she loves.
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Reviewed in the United States on August 25, 2025
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Dave
Whiting, US
★★★★★ 5
One Tough Ball!
Color: Blue
Our dogs are loving this ball. Our 1 yr old hound is a world-class chewer and he can't make a dent in this ball. The interactive buzzing and bouncing keeps them entertained for long durations. It's a mite noisy but the barking from the 1 yr old is much louder, lol. Even turned off, they like playing with it and chewing on it. Based on the tough construction, we think it will last much longer than traditional chew balls.
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Reviewed in the United States on March 22, 2026

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