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Description
MLH1 Recombinant Rabbit mAb (SDT-112-50)Product Specification Host Rabbit Antigen MLH1 Synonyms DNA mismatch repair protein Mlh1, MutL protein homolog 1, COCA2 Immunogen Synthetic Peptide Location Nucleus Accession P40692 Clone Number SDT 112 50 Antibody Type Recombinant mAb Application WB, ICC Reactivity Hu Predicted Reactivity Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin
Product Specification
| Host | Rabbit |
| Antigen | MLH1 |
| Synonyms | DNA mismatch repair protein Mlh1, MutL protein homolog 1, COCA2 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P40692 |
| Clone Number | SDT-112-50 |
| Antibody Type | Recombinant mAb |
| Application | WB, ICC |
| Reactivity | Hu |
| Predicted Reactivity | Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| ICC | 1:50 |
Background
DNA mismatch repair protein Mlh1 or MutL protein homolog 1 is a protein that in humans is encoded by the MLH1 gene located on chromosome 3. It is a gene commonly associated with hereditary nonpolyposis colorectal cancer. MLH1 protein is one component of a system of seven DNA mismatch repair proteins that work coordinately in sequential steps to initiate repair of DNA mismatches in humans [PMID: 18543306]. Defects in mismatch repair, found in about 13% of colorectal cancers, are much more frequently due to deficiency of MLH1 than deficiencies of other DNA mismatch repair proteins [PMID: 15887099]. The seven DNA mismatch repair proteins in humans are MLH1, MLH3, MSH2, MSH3, MSH6, PMS1 and PMS2 [ PMID: 18543306].
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