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Description
Fas/TNFRSF6/CD95 Fc Chimera Protein, RatProduct Specification Species Rat Synonyms FAS,ALPS1A,APO1,APT1,CD95,FAS1,FASTM,TNFRSF6,FasR Accession NP_631933. 2 Amino Acid Sequence Gln22 Lys170, with hIgG Fc Expression System HEK293 Molecular Weight 50 70kDa(R) Purity 95% by SDS PAGE & SEC HPLC Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure
Product Specification
| Species | Rat |
| Synonyms | FAS,ALPS1A,APO1,APT1,CD95,FAS1,FASTM,TNFRSF6,FasR |
| Accession | NP_631933.2 |
| Amino Acid Sequence | Gln22-Lys170, with hIgG Fc |
| Expression System | HEK293 |
| Molecular Weight | 50-70kDa(R) |
| Purity | ＞95% by SDS-PAGE & SEC-HPLC |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1.Peter ME, et al. (2005) Does CD95 have tumor promoting activities Biochim Biophys Acta. 1755(1): 25-36. |
Background
CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. Changes in the expression of CD95 and/or its ligand CD95L are frequently found in human cancer. Impairment of CD95-mediated apoptosis results in defective affinity maturation and the persistence of autoreactive B-cell clones.The downregulation or mutation of CD95 has been proposed as a mechanism by which cancer cells avoid destruction by the immune system through reduced apoptosis sensitivity. Thus, CD95 has therefore been viewed as a tumor suppressor. CD95 has been reported to be involved in the activation of NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and the alternate pathways for CTL-mediated cytotoxicity. Accordingly, this protein is implicated in the pathogenesis of various malignancies and diseases of the immune system. The CD95/CD95L system was implicated in the etiology of inflammatory bowel disease (IBD) based, primarily, on the finding that CD95 is highly expressed in the intestinal epithelial cells and that epithelial apoptosis is increased in IBD.
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