Pay in installments of $30.00 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 27 - Sep 1
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
IL-10 Protein, HumanProduct Specification Species Human Synonyms IInterleukin 10; IL 10; Cytokine synthesis inhibitory factor; CSIF; IL10; RP11 262N9. 1; IL10A; MGC126450; MGC126451; TGIF Accession P22301 Amino Acid Sequence Ser19 Asn178 Expression System E. coli Molecular Weight 19kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH6. 5 Reconstitution Reconstitute at
Product Specification
| Species | Human |
| Synonyms | IInterleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF; IL10; RP11-262N9.1; IL10A; MGC126450; MGC126451; TGIF |
| Accession | P22301 |
| Amino Acid Sequence | Ser19-Asn178 |
| Expression System | E.coli |
| Molecular Weight | 19kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH6.5 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1. Kim JM, Brannan CI, Copeland NG, et al. 1992. J Immunol. 148:3618-23. 2. Tan JC, Braun S, Rong H, et al. 1995. J Biol Chem. 270:12906-11. 3. Pestka S, Krause CD, Sarkar D, et al. 2004. Annu Rev Immunol. 22:929-79. |
Background
Interleukin 10(IL10), also known as cytokine
synthesis inhibitory factor (CSIF),is a secreted protein and belongs to the
IL-10 family. IL-10 is secreted by many activated hematopoietic cell types as
well as hepatic stellate cells, keratinocytes, and placental cytotrophoblasts .
IL-10 is an anti-inflammatory TH2 cytokine that has a critical role in limiting
the immune response to pathogens to prevent host damage. As IL-10 in produced
in several T helper populations, it is proposed that it provides a feedback
loop to limit the effector functions of macrophages and DCs on T cells. Once
expressed, IL-10 signals through the IL-10 receptor (IL-10R) to activate STAT3.
As IL-10 is a strong inhibitor of inflammation, it has become a viable
biomarker for various diseases and conditions as well as a therapeutic molecule
for certain conditions. In addition to elevated levels in parasitic infection,
high expression levels of IL-10 are also found in retroviral infections
inducing immunodeficiency. The immunosuppressive properties of IL-10 suggest a
possible clinical use of IL-10 in suppressing rejections of grafts after organ
transplantations.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy