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Description
Alexa Fluor® 488 Rat Anti-Mouse I-A/I-E Antibody (S-R511)Product Specification Host Rat Antigen I A I E Synonyms H 2 class II histocompatibility antigen, I A beta chain; H2 Eb1; Histocompatibility 2, class II antigen E beta2; H2 Eb2 Location Membrane Accession P18468Q3U060 Clone Number S R511 Antibody Type Rat mAb Isotype IgG2b,k Application FCM Reactivity Ms Positive Sample BALB c mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid
Product Specification
| Host | Rat |
| Antigen | I-A/I-E |
| Synonyms | H-2 class II histocompatibility antigen, I-A beta chain; H2-Eb1; Histocompatibility 2, class II antigen E beta2; H2-Eb2 |
| Location | Membrane |
| Accession | P18468、Q3U060 |
| Clone Number | S-R511 |
| Antibody Type | Rat mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
I-A/I-E proteins are part of the Major Histocompatibility Complex (MHC) class II molecules, which are heterodimeric transmembrane glycoproteins expressed on antigen-presenting cells such as dendritic cells, macrophages, and B cells. These proteins are encoded by four genes located in the mouse MHC and are composed of α and β subunits. The I-A and I-E molecules are highly polymorphic and can form hybrid molecules in heterozygous individuals, contributing to the diversity of antigen presentation. They play a crucial role in presenting peptide antigens to CD4+ helper T cells, initiating adaptive immune responses. Additionally, MHC class II molecules can trigger intracellular signaling pathways in antigen-presenting cells, influencing their proliferation, maturation, and apoptosis.
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Exchange/Return Notes
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