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Description
BMAL1 Recombinant Rabbit mAb (S-1918-155)Product Specification Host Rabbit Antigen BMAL1 Synonyms Basic helix loop helix ARNT like protein 1; Aryl hydrocarbon receptor nuclear translocator like protein 1; Basic helix loop helix PAS protein MOP3; Brain and muscle ARNT like 1; Class E basic helix loop helix protein 5 (bHLHe5); Member of PAS protein 3; ARNTL; BHLHE5; MOP3; PASD3 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession O00327 Clone Number S 1918 155 Antibody Type
Product Specification
| Host | Rabbit |
| Antigen | BMAL1 |
| Synonyms | Basic helix-loop-helix ARNT-like protein 1; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic-helix-loop-helix-PAS protein MOP3; Brain and muscle ARNT-like 1; Class E basic helix-loop-helix protein 5 (bHLHe5); Member of PAS protein 3; ARNTL; BHLHE5; MOP3; PASD3 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | O00327 |
| Clone Number | S-1918-155 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, SH-SY5Y, PC-3, Raji, NIH/3T3, mouse liver, rat liver |
| Predicted Reactivity | Or,Hr,Hm,Ck |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:2000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms |
Background
BMAL1 (Brain and muscle ARNT-like 1, also known as ARNTL) is a bHLH/PAS-domain transcription factor that forms a heterodimer with CLOCK (or NPAS2) to drive the transcription of clock-controlled genes (e.g., Per and Cry) via E-box elements, thereby operating as the positive limb of the circadian transcription-translation feedback loop essential for generating ~24-hour molecular rhythms; it is the only clock gene whose loss abolishes circadian rhythmicity in mammals and whose disruption is linked to a spectrum of disorders including metabolic syndrome, psychiatric and neurodegenerative diseases, infertility, and altered sleep, while also regulating adipogenesis, immune responses, embryonic development, and protein synthesis through interactions with metabolic and signaling pathways.
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