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Description
Bcl-xL His Tag Protein, HumanProduct Specification Species Human Synonyms Bcl 2 Like Protein 1; Bcl2 L 1; Apoptosis Regulator Bcl X; BCL2L1; BCL2L; BCLX Accession Q07817 Amino Acid Sequence Met1 Arg212 Expression System E. coli Molecular Weight 24. 85 KDa Purity >95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Liquid Storage Buffer 20mM HEPES, 50mM KCl, 20% Glycerol, pH 7. 5. Stability & Storage Store at 70C, stable for 6 months after
Product Specification
| Species | Human |
| Synonyms | Bcl-2-Like Protein 1; Bcl2-L-1; Apoptosis Regulator Bcl-X; BCL2L1; BCL2L; BCLX |
| Accession | Q07817 |
| Amino Acid Sequence |
Met1-Arg212
|
| Expression System | E.coli |
| Molecular Weight |
24.85 KDa
|
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Liquid |
| Storage Buffer | 20mM HEPES, 50mM KCl, 20% Glycerol, pH 7.5. |
| Stability & Storage |
|
Background
Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1 is a mitochondrial membrane protein. BCL2L1 contains four motifs, BH1, BH2 and BH4. The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death. BCL2L1 regulates cell death by blocking the voltage-dependent anion channnel (VDAC) and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. In addition, BCL2L1 promotes apoptosis.
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