SKU: 19279568468

PSME4 Recombinant Rabbit mAb (S-3132-44)

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Description

PSME4 Recombinant Rabbit mAb (S-3132-44)Product Specification Host Rabbit Antigen PSME4 Synonyms Proteasome activator complex subunit 4; Proteasome activator PA200; Protein BLM10 homolog (Blm10; hBlm10); BLM10; KIAA0077; PSME4 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q14997 Clone Number S 3132 44 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample 293T, K562, HeLa, HepG2, RAW264. 7, mouse heart, mouse testis,

Product Specification


Host Rabbit
Antigen PSME4
Synonyms Proteasome activator complex subunit 4; Proteasome activator PA200; Protein BLM10 homolog (Blm10; hBlm10); BLM10; KIAA0077; PSME4
Immunogen Synthetic Peptide
Location Cytoplasm, Nucleus
Accession Q14997
Clone Number S-3132-44
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, ICC
Reactivity Hu, Ms, Rt
Positive Sample 293T, K562, HeLa, HepG2, RAW264.7, mouse heart, mouse testis, mouse pancreas, C6, rat heart, rat testis
Predicted Reactivity Bv, Xe
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt
IHC-P 1:500 Hu, Ms, Rt
ICC 1:500 Hu, Ms, Rt

Background

PSME4 (Proteasome Activator Subunit 4), also known as PA200 or Blm10 in yeast, is a nuclear proteasome activator that uniquely stimulates the peptidase activity of the 20S core particle through a gate-opening mechanism independent of ATP and ubiquitin conjugation. Structurally, PSME4 contains an HbYX (hydrophobic-tyrosine-X) motif at its C-terminus that docks into the inter-subunit pockets of the 20S α-ring, inducing conformational changes that facilitate substrate entry into the catalytic chamber. Unlike the ATP-dependent 19S regulatory particle or the PA28/11S REG family, PSME4 forms a dome-shaped homodimer that caps the 20S proteasome and preferentially promotes the degradation of unstructured peptides and certain natively disordered proteins, including acetylated histones and unstructured regions of prion-like proteins. PSME4 plays critical roles in spermatogenesis, where it is highly expressed in testis and essential for histone-to-protamine exchange during sperm chromatin remodeling, as well as in DNA damage response and cellular stress adaptation. Dysregulation of PSME4 has been implicated in various pathological conditions, including male infertility, neurodegenerative disorders characterized by protein aggregation, and cancer, where its expression levels correlate with tumor progression and therapeutic resistance in certain malignancies.

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SKU: 19279568468

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