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Description
Biotin Mouse Anti-Human CD42a Antibody (S-4391)Product Specification Host Mouse Antigen CD42a Synonyms Platelet glycoprotein IX; GP IX; GPIX; Glycoprotein 9; GP9 Location Membrane Accession P14770 Clone Number S 4391 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Fresh human peripheral blood cells Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability & Storage 12
Product Specification
| Host | Mouse |
| Antigen | CD42a |
| Synonyms | Platelet glycoprotein IX; GP-IX; GPIX; Glycoprotein 9; GP9 |
| Location | Membrane |
| Accession | P14770 |
| Clone Number | S-4391 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Fresh human peripheral blood cells |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
CD42a, also known as glycoprotein IX (GPIX), is an essential subunit of the platelet surface glycoprotein Ib-IX-V complex. This complex serves as the primary receptor for von Willebrand factor (vWF) and plays a central role in platelet adhesion, thrombus formation, and primary hemostasis. CD42a non-covalently associates with other subunits such as glycoprotein Ibα (GPIbα) and glycoprotein Ibβ (GPIbβ) to maintain the structural stability and proper membrane expression of the receptor complex. Upon vascular injury, the CD42a-containing complex rapidly binds exposed vWF, mediating firm platelet adhesion to the subendothelial matrix under high shear stress and initiating downstream signaling that leads to platelet activation and aggregation. Mutations in the CD42a gene (GP9) cause the rare autosomal recessive disorder Bernard-Soulier syndrome, characterized by giant platelets, thrombocytopenia, and a severe bleeding tendency. Furthermore, as a platelet-specific marker, CD42a holds significant value in flow cytometry, quality assessment of platelet transfusion, and research into the pathological mechanisms of thrombotic disorders.
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Exchange/Return Notes
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