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Description
BCL-6 Recombinant Rabbit mAb (S-R634)Product Specification Host Rabbit Antigen BCL 6 Synonyms B cell lymphoma 6 protein; BCL 6; B cell lymphoma 5 protein (BCL 5); Protein LAZ 3; Zinc finger and BTB domain containing protein 27; Zinc finger protein 51; BCL5; LAZ3; ZBTB27; ZNF51; BCL6 Location Nucleus Accession P41182 Clone Number S R634 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample Ramos Purification Protein A Concentration 0. 5 mg
Product Specification
| Host | Rabbit |
| Antigen | BCL-6 |
| Synonyms | B-cell lymphoma 6 protein; BCL-6; B-cell lymphoma 5 protein (BCL-5); Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51; BCL5; LAZ3; ZBTB27; ZNF51; BCL6 |
| Location | Nucleus |
| Accession | P41182 |
| Clone Number | S-R634 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | Ramos |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu |
| IHC-P | 1:100 | Hu, Ms, Rt |
Background
BCL-6 protein is a transcriptional repressor that plays a crucial role in the regulation of B cell differentiation and proliferation. It is primarily expressed in germinal center B cells and is essential for the formation and function of germinal centers, which are specialized microenvironments within lymphoid tissues where B cells undergo somatic hypermutation and class switch recombination to generate high-affinity antibodies. BCL-6 achieves its regulatory functions by binding to specific DNA sequences in the promoters of target genes, thereby inhibiting their transcription. Abnormal expression or function of BCL-6 is associated with various B cell lymphomas, making it an important biomarker and therapeutic target in the study and treatment of these malignancies.
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