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Description
PCSK9 His Tag Protein, HumanProduct Specification Species Human Synonyms Proprotein Convertase Subtilisin Kexin Type 9; Neural Apoptosis Regulated Convertase 1; NARC 1; Proprotein Convertase 9; PC9; Subtilisin Kexin Like Protease PC9; PCSK9; NARC1 Accession Q8NBP7 Amino Acid Sequence Gln31 Gln692, with C terminal His Expression System HEK293 Molecular Weight Theoretical: 72. 7kDa Actual: 65kDa Purity 95% by SDS PAGE&>95% by SEC HPLC Endotoxin <1EU g Tag His Tag Physical
Product Specification
| Species | Human |
| Synonyms | Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1 |
| Accession | Q8NBP7 |
| Amino Acid Sequence | Gln31-Gln692, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight |
Theoretical:72.7kDa Actual:65kDa
|
| Purity | ＞95% by SDS-PAGE&>95% by SEC-HPLC |
| Endotoxin | <1EU/μg |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer |
PBS, pH7.4.
|
| Reconstitution |
Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
|
| Stability & Storage |
|
Background
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.
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