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Description
Rab32 Recombinant Rabbit mAb (S-1936-49)Product Specification Host Rabbit Antigen Rab32 Synonyms Ras related protein Rab 32; RAB32 Immunogen Synthetic Peptide Location Mitochondrion Accession Q13637 Clone Number S 1936 49 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample HL 60, HeLa, HepG2, NIH 3T3, C6 Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0.
Product Specification
| Host | Rabbit |
| Antigen | Rab32 |
| Synonyms | Ras-related protein Rab-32; RAB32 |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | Q13637 |
| Clone Number | S-1936-49 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HL-60, HeLa, HepG2, NIH/3T3, C6 |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
Rab32 is a small GTPase protein belonging to the RAS oncogene family, involved in various cellular processes including mitochondrial dynamics, autophagy, and vesicle trafficking. It anchors the type II regulatory subunit of protein kinase A to the mitochondrial outer membrane, facilitating mitochondrial fission. Rab32 also interacts with LRRK2, a protein implicated in Parkinson's disease, and its variants have been identified as a susceptibility factor for familial Parkinson's disease. In cancer biology, Rab32 promotes glioblastoma migration and invasion by regulating ERK/Drp1-mediated mitochondrial fission. Additionally, it plays a role in the degradation of mitochondrial-proximal ER membranes through autophagy, mediated by its effector reticulon 3L.
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