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Description
Mouse Anti-Human CD32 (FcyRllA) Antibody (S-R392)Product Specification Host Mouse Antigen CD32 (FcyRllA) Synonyms Low affinity immunoglobulin gamma Fc region receptor II a; IgG Fc receptor II a; CDw32; Fc gamma RII a (Fc gamma RIIa; FcRII a); FCG2; FCGR2A1; IGFR2; FCGR2A Location Cell membrane Accession P12318 Clone Number S R392 Antibody Type Mouse mAb Isotype IgG2b,k Application FCM Reactivity Hu Positive Sample human peripheral blood leukocyte Purification Protein A Concentration 2 mg ml
Product Specification
| Host | Mouse |
| Antigen | CD32 (FcyRllA) |
| Synonyms | Low affinity immunoglobulin gamma Fc region receptor II-a; IgG Fc receptor II-a; CDw32; Fc-gamma RII-a (Fc-gamma-RIIa; FcRII-a); FCG2; FCGR2A1; IGFR2; FCGR2A |
| Location | Cell membrane |
| Accession | P12318 |
| Clone Number | S-R392 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2b,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | human peripheral blood leukocyte |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | Hu |
Background
CD32 (FcγRIIA) is a 40-kDa type I transmembrane glycoprotein of the Ig superfamily expressed on monocytes/macrophages, granulocytes, dendritic cells, B cells, platelets, and placental endothelium; it contains two extracellular Ig-like domains and functions as a low-affinity receptor for complexed/aggregated IgG (Kd < 10⁻⁷ M) that mediates phagocytosis, respiratory burst, ADCC, and immune complex clearance, with the FcγRIIA (CD32a) isoform delivering activating signals via an intracellular ITAM motif, while the FcγRIIB (CD32b) isoform delivers inhibitory signals via an ITIM motif, and polymorphisms and alternative splicing of the FCGR2A/FCGR2B/FCGR2C genes generate multiple isoforms with distinct expression patterns and functional roles .
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