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Description
Fbx32 Recombinant Rabbit mAb (S-2442-8)Product Specification Host Rabbit Antigen Fbx32 Synonyms F box only protein 32; Atrogin 1; Muscle atrophy F box protein (MAFbx); FBXO32 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q969P5 Clone Number S 2442 8 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Ms Positive Sample mouse skeletal muscle, mouse heart Predicted Reactivity Pg,Rt,Bv Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | Fbx32 |
| Synonyms | F-box only protein 32; Atrogin-1; Muscle atrophy F-box protein (MAFbx); FBXO32 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q969P5 |
| Clone Number | S-2442-8 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Ms |
| Positive Sample | mouse skeletal muscle, mouse heart |
| Predicted Reactivity | Pg,Rt,Bv |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Ms |
Background
Fbx32, also known as Atrogin-1 or MAFbx, is an F-box protein that functions as the substrate-recognition component of the Skp1-Cul1-F-box (SCF) E3 ubiquitin ligase complex, selectively targeting key muscle proteins such as MyoD, eIF3-f, and calcineurin for polyubiquitination and proteasomal degradation, thereby regulating skeletal muscle atrophy in response to catabolic signals like glucocorticoids, inflammatory cytokines, and denervation, while its expression is controlled by the FoxO transcription factors and its inhibition or deletion attenuates muscle wasting in various disease models.
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