Phospho-c-Jun (Ser73) Recombinant Rabbit mAb (S-3105-71)

Phospho-c-Jun (Ser73) refers to the specific post-translational modification where the transcription factor c-Jun is phosphorylated at its serine 73 residue. As a key component of the Activator Protein-1 (AP-1) transcription complex, c-Jun's activity is tightly regulated by the c-Jun N-terminal kinase (JNK) signaling pathway. Upon cellular exposure to stress signals such as UV radiation, cytokine stimulation, or genotoxic stress, JNK becomes activated through phosphorylation and subsequently phosphorylates c-Jun specifically at Ser73. This phosphorylation event is crucial for enhancing c-Jun's transcriptional activity, significantly potentiating the expression of its target genes that govern critical cellular processes including proliferation, differentiation, apoptosis, and inflammatory responses. Consequently, the phosphorylation level at Ser73 serves as a well-established readout for JNK pathway activation, and researchers commonly detect this modification using phospho-specific antibodies through techniques like Western Blotting to assess cellular stress response intensity and related signal transduction events.