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Description
TIE2 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms TIE2, Tie 2, TEK, VMCM, VMCM1, CD202b, Angiopoietin 1 receptor Accession G7PS68 Amino Acid Sequence Ala23 Lys745, with C 8*His Expression System HEK293 Molecular Weight 90 105kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure
Product Specification
| Species | Cynomolgus |
| Synonyms | TIE2, Tie-2, TEK, VMCM, VMCM1, CD202b, Angiopoietin-1 receptor |
| Accession | G7PS68 |
| Amino Acid Sequence | Ala23-Lys745, with C-8*His |
| Expression System | HEK293 |
| Molecular Weight | 90-105kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Jones N. et al. (1998) The Tek / Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. Oncogene. 17(9): 1097-1108. 2、Sato A. et al. (1998) Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. Int Immunol. 10(8): 1217-1227. |
Background
Tie-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. Tyrosine-protein kinase that acts as cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of proinflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis.
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4.9 ★★★★★
Based on 24 reviews
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Product Reviews
★★★★★ 5
doggy toy chicken leg
Color: Yellow - Fried Chicken Leg
I bought this chicken leg toy for my dog and it quickly became one of his favorites. The yellow top part has two different sections — the very top makes a crinkly sound like paper when he bites it, and the middle squeaks when he chews or presses on it, which really keeps him interested. The white bottom part is super soft and easy for me to hold, so it’s great for playing tug or just interacting with him. The size is perfect for small dogs, but it might feel a bit small for larger breeds — that said, the material quality is really nice. Overall, it feels well made, fun, and keeps my dog entertained without getting bored. Definitely a good buy.
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Reviewed in the United States on January 4, 2026
★★★★★ 4
Fun, engaging, and cute toy for dogs!
Color: Yellow - Fish Skewer, Color: Yellow - Fish Skewer
I got the fried fish toy for my dog. So far, he really enjoys the squeaking noise and comes running every time he hears it. The toy material is pretty thick and is holding up well during playtime. The size of this toy is perfect for my small dog but it might be a bit small for larger dogs.
Overall it's a fun and super cute toy for my pets that's become a favorite!
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Reviewed in the United States on December 31, 2025
★★★★★ 5
Fun enrichment
Color: Yellow - Fish Skewer, Color: Yellow - Fish Skewer
Bought this to keep my dog busy while I’m out, and surprisingly it works. It’s soft, lightweight, and he was interested right away. Hiding treats inside turns it into a sniffing challenge that keeps him occupied longer than expected.
The squeaker does its job, and the material feels gentle, but this is not for heavy chewers. If your dog destroys toys for sport, proceed with caution.
Overall, it’s a fun enrichment toy that helps with boredom. Great for light to moderate play and dogs who don’t choose violence every day.
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Reviewed in the United States on January 7, 2026
★★★★★ 5
Really cute and great for photos
Color: Yellow - Fried Chicken Leg, Color: Yellow - Fried Chicken Leg
This drumstick plush toy is super cute and looks great in pictures. My dog liked it right away and keeps carrying it around.
It’s soft, lightweight, and the size is just right. We’ve already taken a few fun photos with it, and it would also make a nice little gift for someone with a dog.
Simple, well made, and definitely worth it.
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Reviewed in the United States on January 4, 2026
★★★★★ 2
Don't Bother Unless You Have Something The Size of a Chihuahua
Color: Yellow - Fried Chicken Leg
Title is definitely deceiving. We have 2 Pitbulls and a Bull Terrier. They simply looked at this thing and it blew into pieces. These are more for smaller dogs. I wouldn't even say medium. It was just a big disappointment. I was excited to give them this toy, until it arrived and I saw how small it was.
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Reviewed in the United States on January 3, 2026
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