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Description
DNAM-1/CD226 His Tag Protein, HumanProduct Specification Species Human Accession Q15762 Amino Acid Sequence Glu19 Asn247, with C terminal 8*His EEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNGGGSHHHHHHHH Expression System HEK293 Molecular Weight 44 57 kDa(Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g
Product Specification
| Species | Human |
| Accession | Q15762 |
| Amino Acid Sequence | Glu19-Asn247, with C-terminal 8*His EEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 44-57 kDa(Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
DNAX accessory molecule 1 (DNAM-1; CD226) is a costimulatory molecule belonging to the immunoglobulin superfamily. DNAM-1 is primarily expressed on NK and CD8 T cells, which has been shown to enhance the cytotoxic effector function of NK cells and T cells against tumor- and virus-infected cells. DNAM-1 is a member of the Ig superfamily, encoded by a gene on human chromosome 18q22.3, is expressed by human NK cells, T cells, a subset of B cells, monocytes and platelets. Interactions between DNAM-1 on NK cells and its ligands on tumour cells augments the NK cell–mediated cytotoxicity and cytokine production. CD155 and its related family member CD112, the known ligands for DNAM-1, broadly expressed on hematopoietic, epithelial, and endothelial cells. Moreover, it was shown that the interaction of DNAM-1 with CD112 and CD155 contributes to the NK-mediated lysis of both imDCs and mDCs. NK cells also express CD96, which shows only ~20% homology to DNAM-1 but was also shown to recongnize CD155 and promote NK cell adhesion and activation. Decreased NK cell activity has been observed in patients with PDAC, and pancreatic cancer patients have less CD226+ NK cells in the blood than do healthy controls. Dysregulation of DNAM-1 is associated with susceptibility to juvenile idiopathic arthritis, type 1 diabetes (T1D), lupus, and rheumatoid arthritis in patients.
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4.8 ★★★★★
Based on 30 reviews
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Product Reviews
★★★★★ 5
Very helpful
Size: 1.5 Ounce (Pack of 5)
My husband had throat cancer approximately 5 years ago. Treated with chemo and radiation. The radiation burned his saliva glands. This really helps him keep moisture in his mouth. I have it on an auto delivery every 6 weeks (pack of 6)
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Reviewed in the United States on May 30, 2026
★★★★★ 5
Part of my daily routine for radiation caused dry mouth
Size: 1.5 Ounce (Pack of 5)
This product and xylitol lozenges by xylimelt plus taping my mouth closed as night for sleep make for a comfortable solution to my radiation induced dry mouth condition. Recommended.
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Reviewed in the United States on April 30, 2026
★★★★★ 5
It works
Size: 1.5 Ounce (Pack of 5)
I have one by my pillow at night to use.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 24, 2026
★★★★★ 5
Works better than expected.
Size: 1 count (Pack of 1)
I really wish this was, like, a gel for running or something because the flavor is really tasty. Not too sweet, but flavorful enough to make sure you use it. It's a nice orange flavor that doesn't taste medicinal. I applied to the front and back of my teeth only and it lasted half the night. Quickly applied more and it lasted the rest of the night. I'm probably applying way too little but I genuinely just tried it so I'm not used to it yet.
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Reviewed in the United States on May 2, 2026
★★★★★ 5
Great gel
Size: 1 count (Pack of 1)
Due to chemo therapy i developed dry mouth and this gel works immediately
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Reviewed in the United States on May 26, 2026