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Description
E-Cadherin Recombinant Rabbit mAb (Alexa Fluor® 488 Conjugate) (S-438-5)Product Specification Host Rabbit Antigen E Cadherin Synonyms Cadherin 1, CAM 120 80, Epithelial cadherin, Uvomorulin, CD324, Uvomorulin, L CAM Immunogen Recombinant Protein Location Cell membrane Accession P12830 Clone Number S 438 5 Antibody Type Recombinant mAb Isotype IgG Application ICC, IF Reactivity Hu, Ms, Rt Purification Protein A Concentration 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 0. 1% BSA, 0.
Product Specification
| Host | Rabbit |
| Antigen | E-Cadherin |
| Synonyms | Cadherin-1, CAM 120/80, Epithelial cadherin, Uvomorulin, CD324, Uvomorulin, L-CAM |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P12830 |
| Clone Number | S-438-5 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | ICC, IF |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 0.1% BSA, 0.01% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilution
| application | dilution | species |
| ICC | 1:200 | null |
| IF | 1:200 | null |
Background
E-cadherin is a transmembrane glycoprotein which connects epithelial cells together at adherens junctions. In normal cells, E-cadherin exerts its tumour suppressing role mainly by sequestering β-catenin from its binding to LEF (Lymphoid enhancer factor)/TCF (T cell factor) which serves the function of transcribing genes of the proliferative Wnt signaling pathway. Despite the ongoing debate on whether the loss of E-cadherin is the cause or effect of epithelial-mesenchymal transition (EMT), E-cadherin functional loss has frequently been associated with poor prognosis and survival in patients of various cancers. The dysregulation of E-cadherin expression that leads to carcinogenesis happens mostly at the epigenetic level but there are cases of genetic alterations as well. E-cadherin expression has been linked to the cellular functions of invasiveness reduction, growth inhibition, apoptosis, cell cycle arrest and differentiation.
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