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Description
MEK1 Recombinant Rabbit mAb (SDT-308-32)Product Specification Host Rabbit Antigen MEK1 Synonyms Dual specificity mitogen activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK 1, MKK1, ERK activator kinase 1, MAPK ERK kinase 1 Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Nucleus, Membrane Accession Q02750 Clone Number SDT 308 32 Application WB, IHC P, ICC, ICFCM, IP Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage
Product Specification
| Host | Rabbit |
| Antigen | MEK1 |
| Synonyms | Dual specificity mitogen-activated protein kinase kinase 1, MAP kinase kinase 1, MAPKK 1, MKK1, ERK activator kinase 1, MAPK/ERK kinase 1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Nucleus, Membrane |
| Accession | Q02750 |
| Clone Number | SDT-308-32 |
| Application | WB, IHC-P, ICC, ICFCM, IP |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied. |
Dilution
| application | dilution | species |
| WB | 1:1000-1:10000 | null |
| IHC-P | 1:500 | null |
| ICC | 1:1000 | null |
| IP | 1:50 | null |
| ICFCM | 1:500 | null |
Background
Mitogen-activated protein kinase kinases 1 and 2 (MEK1/2) are the crucial part of the RAS-RAF-MEK-ERK pathway (or ERK pathway), which is involved in the regulation of various cellular processes including proliferation, survival, and differentiation et al. Targeting MEK has become an important strategy for cancer therapy, and 4 MEK inhibitors (MEKis) have been approved by FDA to date [PMID: 33774345].
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