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Description
S-RMab® CD45 Recombinant Rabbit mAb,PBS Only (SDT-R035)Product Specification Host Rabbit Antigen CD45 Synonyms Leukocyte common antigen (L CA) Immunogen N A Location Cell membrane Accession P08575 Clone Number SDT R035 Antibody Type Rabbit mAb Application WB, IHC P, ICC Reactivity Hu Purification N A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months from date of receipt, 4C as supplied Dilution application dilution species WB 1: 2000
Product Specification
| Host | Rabbit |
| Antigen | CD45 |
| Synonyms | Leukocyte common antigen (L-CA) |
| Immunogen | N/A |
| Location | Cell membrane |
| Accession | P08575 |
| Clone Number | SDT-R035 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Purification | N/A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt, 4°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:2000-1:10000 | |
| IHC-P | 1:250-1:1000 | |
| ICC | 1:250 |
Background
CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells (except erythrocytes and plasma cells). CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain (a form of co-stimulation), or by activating various Src family kinases required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses JAK kinases, and so functions as a negative regulator of cytokine receptor signaling.
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