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Description
NCAM-1/CD56 Mouse mAb (S-577-58)Product Specification Host Mouse Antigen NCAM 1 CD56 Synonyms Neural cell adhesion molecule 1, N CAM 1, NCAM, NCAM 1, NCAM1 Immunogen Recombinant Protein Location Cell membrane Accession P13591 Clone Number S 577 58 Antibody Type Mouse mAb Isotype IgG1, Application FCM Reactivity Hu Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA, 0. 03% Proclin 300 Stability
Product Specification
| Host | Mouse |
| Antigen | NCAM-1/CD56 |
| Synonyms | Neural cell adhesion molecule 1, N-CAM-1, NCAM, NCAM 1, NCAM1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P13591 |
| Clone Number | S-577-58 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,λ |
| Application | FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:2000 | null |
Background
Neural cell adhesion molecule (NCAM), also called CD56, is a homophilic binding glycoprotein expressed on the surface of neurons, glia and skeletal muscle. CD56 is thought to signal to induce neurite outgrowth via the fibroblast growth factor receptor (FGFR) and act upon the p59Fyn signaling pathway. In nerves, CD56 regulates homophilic (like-like) interactions between neurons and between neurons and muscle; it associates with fibroblast growth factor receptor (FGFR) and stimulates tyrosine kinase activity of receptor to induce neurite outgrowth. When neural crest cells stop making CD56 and N-cadherin, and start displaying integrin receptors, cells separate and migrate. During hematopoiesis, CD56 is the prototypic marker of NK cells, also present on subset of CD4+ T cells and CD8+ T cells. In cell adhesion, CD56 contributes to cell-cell adhesion or cell-matrix adhesion during embryonic development.
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