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Description
TWEAK Protein, HumanProduct Specification Species Human Synonyms Tumor necrosis factor ligand superfamily member 12, APO3 ligand, TNF related weak inducer of apoptosis (TWEAK) Accession O43508 Amino Acid Sequence Ser94 His249 Expression System HEK293 Molecular Weight 18 20 kDa (Reducing) Purity >95% by SDS PAGE, >90% by HPLC. Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized powder Storage Buffer PBS, pH7. 4 Reconstitution
Product Specification
| Species | Human |
| Synonyms | Tumor necrosis factor ligand superfamily member 12, APO3 ligand, TNF-related weak inducer of apoptosis (TWEAK) |
| Accession | O43508 |
| Amino Acid Sequence | Ser94-His249 |
| Expression System | HEK293 |
| Molecular Weight | 18-20 kDa (Reducing) |
| Purity | >95% by SDS-PAGE, >90% by HPLC. |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | ·12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | Tumour Biol. 2017 Jun;39(6):1010428317714624. |
Background
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), also known as TNFSF12, is a member of the TNF ligand superfamily initially characterized in 1997. TWEAK is synthesized as a type II transmembrane protein and can be proteolytically cleaved by furin into a soluble cytokine. It exerts its biological functions primarily by binding to its receptor, fibroblast growth factor-inducible 14 (Fn14), which contains a TRAF-binding motif that activates downstream signaling cascades including NF-κB, MAPK, PI3K-Akt, and Notch pathways. While Fn14 is the critical signaling receptor, CD163 can also bind soluble TWEAK as a scavenger receptor. The TWEAK/Fn14 axis regulates diverse cellular processes including proliferation, differentiation, migration, angiogenesis, inflammation, and apoptosis, with Fn14 expression being markedly upregulated during tissue injury, inflammation, and regeneration.
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