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Description
Human Lumican, His tagProduct Specification Species Human Synonyms Keratan sulfate proteoglycan lumican (KSPG lumican) Accession P51884 Amino Acid Sequence Protein sequence(P51884, Gln19 Asn338, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | Keratan sulfate proteoglycan lumican (KSPG lumican) |
| Accession | P51884 |
| Amino Acid Sequence | Protein sequence(P51884, Gln19-Asn338, with C-10*His) |
| Expression System | HEK293 |
| Molecular Weight | Theoretical: 38.3kDa Actual: 46kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage |
|
Background
Lumican is a member of the small leucine-rich proteoglycan family. It is present in numerous extracellular matrices of different tissues, such as muscle, cartilage, and cornea. In skin, lumican is present as a glycoprotein. It plays a critical role in collagen fibrillogenesis, as shown by knocking out of its gene in mice. A direct link between lumican expression and melanoma progression and metastasis has been demonstrated. Lumican was shown to impede tumour cell migration and invasion by directly interacting with the α2β1 integrin. In addition, an active sequence of the lumican core protein, called lumcorin, was identified as being responsible for inhibition of melanoma cell migration. Lumican was also shown to exert angiostatic properties by downregulating the proteolytic activity associated with endothelial cell membranes, particularly matrix metalloproteinase (MMP)-14 and MMP-9.
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- Free Standard Shipping on $100+ Orders to the USA.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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4.1 ★★★★★
Based on 68 reviews
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Product Reviews
★★★★★ 4
Dogs love these!
Size: Small, Color: Pink
My miniature Goldendoodle puppies love these! The only drawback is after several weeks of chewing, the bones develop pretty sharp edges long before the actual bone has been worn down. At that point, they are dangerous for the dog’s gums and must be thrown away.
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Reviewed in the United States on June 3, 2026
★★★★★ 5
🦴 Micro Bone, Major Relief; Perfect Puppy Teething Chew Toy
Size: X-Small, Color: Blue, Size: X-Small, Color: Blue
🐾 Hi, I’m PVD; teething survivor, nub enthusiast, and gum massage advocate.
This tiny blue bone was my day-one favorite from 8 weeks to 5.5 months, it handled every chew session, tantrum, and tooth eruption with dignity. I’ve officially “aged out,” but I still salute it.
⭐ Why it earned 5 stars:
✔️ Perfect XS size for toy breed jaws
✔️ Soft on sore gums, durable enough for dramatic chewing
✔️ Ridges + nubs = mouth spa treatment
✔️ Chilling it = elite teething relief
✔️ Kept me busy and prevented chewing on illegal things (furniture, shoes… mother)
🌀 Why I’m now gracefully retiring it (but still recommending):
✘ Jaw strength and confidence grew but I didn’t vibe with the larger size versions (tried and rejected them with judgment)
✘ Texture now too gentle for my post-teething chew style
✘ Advanced chewers may get bored once the rage-chewing era passes
✘ I get gum relief via Nylabone Nubz edible chews now
Best For:
• XS-Small breed puppies, especially under 5 lbs
• Teething stages + gum relief
• Delicate chewers or fur babies still in the love-bite phase
• First-time puppy parents (trust me, this bone prevents household drama!)
• 8 weeks–6 months old
🚫 Not for adult teeth or advanced chew techniques.
📝 Final Re-Barks:
Iconic starter bone for toy breed pups. Affordable, safe, and genuinely soothing during teething chaos. It carried me through the hardest months (and saved several legs; both human and furniture). I’ve outgrown it; but I’ll forever endorse it for the next generation of tiny chewers.
— PVD (Tiny Tooth Graduate, Former Chew Therapy Success Story 🧊🦴)
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Reviewed in the United States on September 17, 2025
★★★★★ 3
Nylabone Puppy Treat Starter Pack - A Mixed Bag of Delight and Disappointment
Size: Small, Color: Blue
I recently purchased the Nylabone Puppy Treat Starter Pack for my adorable 5lb puppy, and overall, I have mixed feelings about this product. While I was initially satisfied with the variety pack, one of the bones in particular left me disappointed due to its lack of durability.
Let's start with the positives. The Nylabone Puppy Treat Starter Pack comes with three different toys: a blue puppy teething toy, a nylon dog toy, and a chew treat. This variety is great for keeping my puppy engaged and entertained, especially during the teething phase. The blue puppy teething toy is specifically designed for soothing sore gums, and my puppy seemed to find great relief when chewing on it. It has a pleasant texture that is gentle on the teeth and gums, making it an ideal choice for teething puppies.
The nylon dog toy included in the pack is durable and sturdy. It has a satisfyingly textured surface that provides an excellent chewing experience for my little furry friend. The toy is designed to withstand the strong chewing habits of puppies, and it has certainly proven to be long-lasting compared to other toys I've tried in the past. My puppy enjoys gnawing on it for extended periods without any signs of damage.
Now, let's address the bone that failed to meet expectations. One of the bones included in the pack was devoured by my puppy within a single evening. I was taken aback by how quickly it was consumed, especially considering my puppy's small size. While the other bones in the pack held up well, this particular one lacked the durability I had hoped for. I understand that puppies have strong jaws, but I expected the bone to withstand more than a few hours of chewing.
Despite this disappointment, I must mention that the bone did not cause any harm to my puppy. It is important to supervise your puppy while they chew on any toys, especially if they have a tendency to swallow large chunks. In this case, I was fortunate that my puppy did not experience any adverse effects after consuming the bone. However, it's crucial to exercise caution and ensure that your puppy doesn't ingest anything that could potentially be harmful.
Overall, while the Nylabone Puppy Treat Starter Pack has its upsides, I cannot ignore the fact that one of the bones failed to meet expectations in terms of durability. However, the other toys included in the pack provided a satisfactory experience for my puppy, and they have proven to be long-lasting. I would recommend this product with the caveat that you closely monitor your puppy's chewing habits and potentially avoid the bone that didn't hold up well in my particular case.
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Reviewed in the United States on May 31, 2023
★★★★★ 5
⭐⭐⭐⭐⭐ Great for teething puppies
Size: Small, Color: Pink
I purchased the Nylabone puppy chew toys for my teething puppy, and they’ve been a big help. The toys are the perfect size for a young puppy and feel durable without being too hard.
My puppy enjoys chewing on them, and they’ve helped redirect chewing away from furniture and shoes. I also like that they’re designed specifically for puppies, so they’re gentle enough for growing teeth and gums.
The variety in the set keeps my puppy interested, and the toys have held up well with daily use. They’re easy to clean and feel safe to give to a puppy.
Overall, these are great chew toys for puppies. They’re effective, well made, and helpful during the teething stage. I would definitely recommend them to new puppy owners.
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Reviewed in the United States on December 15, 2025
★★★★★ 5
Happy puppy with this durable bone
Size: X-Small, Color: Pink
Our new puppy loves the texture and thickness of this bone. She is an aggressive chewed and has not yet destroyed this bone. We have purchased Nylabones for our dogs year after year and have had several happy puppies over the years.
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Reviewed in the United States on June 4, 2026
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